Sln staging for endometrial cancer

Access through your institution Buy or subscribe Women with endometrial cancer who are found to have lymph-node-positive disease during surgical staging by lymphadenectomy benefit from

adjuvant chemotherapy; however, the remaining 78% of women who have node-negative disease do not. Moreover, lymphadenectomy can have adverse effects, including lymphoedema and nerve damage.

New data indicate that sentinel lymph-node (SLN)-based staging is a reliable alternative. In the FIRES prospective cohort study, the diagnostic accuracy of SLN biopsy guided by fluorescence

mapping with indocyanine green dye for the detection of metastases was compared with that of 'gold standard' pelvic ± para-aortic lymphadenectomy. For generalizability, the FIRES

study involved 18 surgeons across 10 centres (tertiary academic or community non-academic). This is a preview of subscription content, access via your institution ACCESS OPTIONS Access

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support REFERENCES * Rossi, E. C. _ et al_. A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort

study. _Lancet Oncol._ http://dx.doi.org/10.1016/S1470-2045(17)30068-2 (2017) Download references Authors * David Killock View author publications You can also search for this author

inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Killock, D. SLN staging for endometrial cancer. _Nat Rev Clin Oncol_ 14, 200

(2017). https://doi.org/10.1038/nrclinonc.2017.25 Download citation * Published: 21 February 2017 * Issue Date: April 2017 * DOI: https://doi.org/10.1038/nrclinonc.2017.25 SHARE THIS ARTICLE

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