Aneuploidy and immune evasion — a biomarker of response

Access through your institution Buy or subscribe Many tumours are characterized by the presence of aneuploidy (an abnormal number of chromosomes), and somatic copy-number alterations

(SCNAs). Immune evasion is another hallmark of cancer, with important implications for resistance to therapy. Studies have shown that cytolytic immune infiltrates correlate with the tumour

mutational load, although the mechanisms underlying this link are not well understood. Now, results of a large analysis indicate that most tumours with extensive aneuploidy have a reduced

number of infiltrating immune cells, which might have predictive potential. > ...indicating that aneuploidy restricts cytotoxic immune processes > during tumorigenesis This is a

preview of subscription content, access via your institution RELEVANT ARTICLES Open Access articles citing this article. * AN ORIGINAL ANEUPLOIDY-RELATED GENE MODEL FOR PREDICTING LUNG

ADENOCARCINOMA SURVIVAL AND GUIDING THERAPY * Yalei Zhang *  & Dongmei Li _Scientific Reports_ Open Access 07 April 2024 ACCESS OPTIONS Access through your institution Access Nature and

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which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Davoli, T. _ et

al_. Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy. _Science_ 355, eaaf8399 (2017) Article  Google Scholar  Download references

Authors * Lisa Hutchinson View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS

ARTICLE Hutchinson, L. Aneuploidy and immune evasion — a biomarker of response. _Nat Rev Clin Oncol_ 14, 140 (2017). https://doi.org/10.1038/nrclinonc.2017.23 Download citation * Published:

20 February 2017 * Issue Date: March 2017 * DOI: https://doi.org/10.1038/nrclinonc.2017.23 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get

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