Pericardial adipose tissue regulates granulopoiesis

Access through your institution Buy or subscribe Immune cells were quantified in the pericardial adipose tissue (AT) of mice before and after myocardial infarction (MI). B cells expressing

granulocyte–macrophage colony-stimulating factor (GM-CSF), dendritic cells, and IL-17-producing T cells expanded in the pericardial AT after MI. B cell depletion or GM-CSF blockade reduced

the number of dendritic cells and T cells in the AT of infarcted hearts. Given that IL-17 promotes granulopoiesis and neutrophil recruitment, B cell depletion also reduced the number of

cardiac neutrophils after MI. These observations show that B cell expansion in pericardial AT after MI activates an inflammatory cascade that induces emergency granulopoiesis. Moreover, B

cell depletion or surgical removal of AT reduced MI-induced cardiac fibrosis, which also suggests that pericardial AT influences cardiac outcomes after MI. This is a preview of subscription

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article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in

* Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Horckmans, M. _ et al_. Pericardial adipose tissue regulates granulopoiesis, fibrosis, and

cardiac function after myocardial infarction. _Circulation_ 137, 948–960 (2018) Article  Google Scholar  Download references Authors * Alexandra Le Bras View author publications You can also

search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Le Bras, A. Pericardial adipose tissue regulates

granulopoiesis. _Nat Rev Cardiol_ 15, 254 (2018). https://doi.org/10.1038/nrcardio.2018.27 Download citation * Published: 15 March 2018 * Issue Date: May 2018 * DOI:

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