A new model to estimate lifetime risk of cvd

Access through your institution Buy or subscribe The researchers prospectively analyzed data from patients registered between 1 January 1994 and 30 April 2010 in 563 primary care centers in

England and Wales. Patient data were obtained from the QResearch® database, in which electronic information routinely collected in primary care centers is stored. The open cohort analyzed in

the study included patients who, at study entry, were aged 30–84 years, free from CVD, and had never taken statins. Importantly, a wide range of risk factors were included in the model,

such as social deprivation, ethnicity, and family history of coronary heart disease. Lifetime risk of CVD was defined as the cumulative risk of developing CVD, and death from

noncardiovascular causes was considered as a competing risk. Two-thirds of the practices were assigned to the derivation cohort (which included 2,343,759 eligible patients) and one-third to

the validation cohort (which included 1,267,159 eligible patients). Comparisons with QRISK2, a previously developed model that predicts the 10-year absolute risk of CVD, show that the new

lifetime risk model identifies younger patients at high risk. These patients are more likely to be men, from nonwhite ethnic groups, and have a family history of coronary heart disease. This

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during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Hippisley-Cox, J. _ et al_.

Derivation, validation, and evaluation of a new QRISK model to estimate lifetime risk of cardiovascular disease: cohort study using QResearch database. _BMJ_ 341, c6624 (2010) Article 

Google Scholar  Download references Authors * Joana Osório View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Osório, J. A new model to estimate lifetime risk of CVD. _Nat Rev Cardiol_ 8, 66 (2011). https://doi.org/10.1038/nrcardio.2010.221 Download

citation * Issue Date: February 2011 * DOI: https://doi.org/10.1038/nrcardio.2010.221 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get

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