Imaging activity in brain cells: deconvolution clears the haze

A deceptively simple signal processing method allows researchers to quantify complex and irregular patterns of high frequency neuronal activity in whole brain at single-neuron resolution by

deconvolving the slow Ca2+ signals generated by neuronal spikes. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution

ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue Learn more Buy this article *

Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn

about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Friston, K. _Annu. Rev. Neurosci._ 25, 221–250 (2002). Article  CAS  Google Scholar  * Miesenbock,

G. & Kevrekidis, I.G. _Annu. Rev. Neurosci._ 28, 533–563 (2005). Article  Google Scholar  * Brustein, E., Marandi, N., Kovalchuk, Y., Drapeau, P. & Konnerth, A. _Pfugers Arch._ 446,

766–773 (2003). Article  CAS  Google Scholar  * Kerr, J.N., Greenberg, D. & Helmchen, F. _Proc. Natl. Acad. Sci. USA_ 102, 14063–14068 (2005). Article  CAS  Google Scholar  * Ikegaya, Y.

_ et al_. _Science_ 304, 559–564 (2004). Article  CAS  Google Scholar  * Smetters, D., Majeska, A. & Yuste, R. _Methods_ 18, 215–221 (1999). Article  CAS  Google Scholar  * Denk, W.,

Strickler, J.H. & Webb, W.W. _Science_ 248, 73–76 (1990). Article  CAS  Google Scholar  * Yaksi, E. & Friedrich, R.W. _Nat. Methods_ 3, 377–383 (2006). Article  CAS  Google Scholar 

Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * the Neurosciences Department, Case Western Reserve University, Cleveland, 44106, Ohio, USA Ben W Strowbridge Authors * Ben W

Strowbridge View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE

Strowbridge, B. Imaging activity in brain cells: deconvolution clears the haze. _Nat Methods_ 3, 344–346 (2006). https://doi.org/10.1038/nmeth0506-344 Download citation * Issue Date: May

2006 * DOI: https://doi.org/10.1038/nmeth0506-344 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is

not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative