Mapping of genetic and epigenetic regulatory networks using microarrays

The highly coordinated expression of thousands of genes in an organism is regulated by the concerted action of hundreds of transcription factors and chromatin proteins, as well as by

epigenetic mechanisms. Understanding the architecture of these vastly complex regulatory networks is one of the main challenges in the postgenomic era. New microarray-based techniques have

become available for the genome-wide mapping of in vivo protein-DNA interactions and epigenetic marks. Data sets obtained with these techniques begin to offer the first comprehensive views

of genetic and epigenetic regulatory networks.

I thank M. Wolkers, F. van Leeuwen, D. Schübeler and members of my laboratory for suggestions. This work was supported by the Human Frontier Science Program, NWO-Genomics, the Dutch Cancer

Society and an EURYI Award.

the Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands

B.v.S. is listed as an inventor on a patent application that was filed for the DamID technology.

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