Empress: standardized phenotype screens for functional annotation of the mouse genome

Access through your institution Buy or subscribe To the editor: With the completion of the genome sequence of several mammals, attention is now focused on functional annotation of these

genomes. The most versatile organism in which to study mammalian gene function is the mouse, as there is an extensive tool kit for modifying the genome including gene-driven and

phenotype-driven approaches1,2,3,4,5,6. Underpinning this diversity is the recognition of the utility of a series of mutated alleles at every gene in the mouse genome. Such a resource would

enable a full exploration of gene-phenotype space and provide a wider collection of models for translating gene function to human disease genetics. Such a program is crucially dependent on

tools to investigate phenotype. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12

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HISTORY * _ 22 AUGUST 2006 In the supplementary information initially published online to accompany this article, the name of one of the contributors was inadvertently omitted from the

Supplementary Note. The original file has been replaced with a corrected version. The error has been corrected online _ * _ 15 FEBRUARY 2022 A Correction to this paper has been published:

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mutagenesis program. _Nat. Genet._36, 925–927 (2004). Download references AUTHOR INFORMATION Author notes * S.D.M. Brown, P. Chambon and M. Hrabé de Angelis: contributed equally to this

work. CONSORTIA THE EUMORPHIA CONSORTIUM * S.D.M. Brown * , P. Chambon *  & M. Hrabé de Angelis ADDITIONAL INFORMATION A list of all members of The Eumorphia Consortium and their

affiliations is given in Supplementary Note online. SUPPLEMENTARY INFORMATION SUPPLEMENTARY NOTE RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE The

Eumorphia Consortium. EMPReSS: standardized phenotype screens for functional annotation of the mouse genome. _Nat Genet_ 37, 1155 (2005). https://doi.org/10.1038/ng1105-1155 Download

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