Prognostic factors affecting pancreatic adenocarcinoma

Sagol Ö et al. (2005) The effect of apoptotic activity, survivin, Ki-67, and P-glycoprotein expression on prognosis in pancreatic carcinoma. Pancreas 30: 343–348

Pancreatic cancer is an aggressive and intrinsically therapy-resistant and drug-resistant neoplasm, with consequently poor prognosis. In order to clarify the underlying pathogenetic

mechanisms of pancreatic adenocarcinoma, a group from Turkey has investigated the roles of apoptosis, SURVIVIN, tumor-cell proliferation and P-GLYCOPROTEIN in the behavior of this disease.

This article was published with the same DOI as a previous publication. A new DOI has been assigned and registered at Crossref, and has been corrected in the article.

A member of the 'inhibitor of apoptosis' family of negative regulatory proteins that prevent apoptotic cell death; gene expression is high during fetal development and in most tumors, but

low in adult tissues

An ATP-binding plasma membrane protein; overexpression confers multidrug resistance to tumor cells by expelling cytotoxic drugs

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