Prognostic factors affecting pancreatic adenocarcinoma

Access through your institution Buy or subscribe Sagol Ö _et al_. (2005) The effect of apoptotic activity, survivin, Ki-67, and P-glycoprotein expression on prognosis in pancreatic

carcinoma. _Pancreas_ 30: 343–348 Pancreatic cancer is an aggressive and intrinsically therapy-resistant and drug-resistant neoplasm, with consequently poor prognosis. In order to clarify

the underlying pathogenetic mechanisms of pancreatic adenocarcinoma, a group from Turkey has investigated the roles of apoptosis, SURVIVIN, tumor-cell proliferation and P-GLYCOPROTEIN in the

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17 MAY 2018 This article was published with the same DOI as a previous publication. A new DOI has been assigned and registered at Crossref, and has been corrected in the article. _ GLOSSARY

* SURVIVIN A member of the 'inhibitor of apoptosis' family of negative regulatory proteins that prevent apoptotic cell death; gene expression is high during fetal development and

in most tumors, but low in adult tissues * P-GLYCOPROTEIN An ATP-binding plasma membrane protein; overexpression confers multidrug resistance to tumor cells by expelling cytotoxic drugs

RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Prognostic factors affecting pancreatic adenocarcinoma. _Nat Rev Gastroenterol Hepatol_ 2, 345 (2005).

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