Angiogenesis occurs at the onset of the dysplastic stage of colorectal cancer development

Access through your institution Buy or subscribe Staton CA _ et al_. (2007) The angiogenic switch occurs at the adenoma stage of the adenoma–carcinoma sequence in colorectal cancer. _Gut_

56: 1426–1432 In addition to its role as a key initiator of blood coagulation, tissue factor (TF) also upregulates vascular endothelial growth factor (VEGF), a highly potent stimulator of

angiogenesis. The stage at which angiogenesis begins (the 'angiogenic switch') in the adenoma–carcinoma sequence (ACS) of colorectal cancer progression, however, is not clear.

Staton and colleagues therefore examined the expression of TF and VEGF and microvascular density at different stages of colorectal cancer. This is a preview of subscription content, access

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occurs at the onset of the dysplastic stage of colorectal cancer development. _Nat Rev Gastroenterol Hepatol_ 4, 645 (2007). https://doi.org/10.1038/ncpgasthep0970 Download citation * Issue

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