Antiphospholipid antibodies from a patient with primary antiphospholipid syndrome enhance experimental atherosclerosis

ABSTRACT BACKGROUND A 35-year-old man with primary antiphospholipid syndrome and no risk factors for atherosclerosis presented with postinfarction angina. INVESTIGATIONS Coronary

angiography, intravascular ultrasonography, injection of apolipoprotein–E-knockout mice with patient's IgG. DIAGNOSIS Myocardial infarction caused by a newly occluded proximal left

circumflex artery. The left anterior descending artery exhibited a recanalized thrombus throughout the vessel. MANAGEMENT The patient was managed by intensive angicoagulation including

aspirin, clopidogrel, and enoxaparin for 2 months. After follow-up coronary angiography, he was switched to warfarin with a target International Normalized Ratio of 3.5–4.0. Access through

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AFFILIATIONS * G Keren is Chairman and J George is a Professor at the Department of Cardiology, A Adler is a Resident, A Afek and Y Levy are both Senior Lecturers, Tel Aviv Sourasky Medical

Center, Tel Aviv, Israel., Arnon Adler, Arnon Afek, Yair Levy, Gad Keren & Jacob George Authors * Arnon Adler View author publications You can also search for this author inPubMed Google

Scholar * Arnon Afek View author publications You can also search for this author inPubMed Google Scholar * Yair Levy View author publications You can also search for this author inPubMed 

Google Scholar * Gad Keren View author publications You can also search for this author inPubMed Google Scholar * Jacob George View author publications You can also search for this author

inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Jacob George. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing financial interests. RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Adler, A., Afek, A., Levy, Y. _et al._ Antiphospholipid antibodies from a patient with primary antiphospholipid

syndrome enhance experimental atherosclerosis. _Nat Rev Cardiol_ 6, 215–218 (2009). https://doi.org/10.1038/ncpcardio1436 Download citation * Received: 25 February 2008 * Accepted: 10

November 2008 * Published: 13 January 2009 * Issue Date: March 2009 * DOI: https://doi.org/10.1038/ncpcardio1436 SHARE THIS ARTICLE Anyone you share the following link with will be able to

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