Antenatal steroid use and neonatal outcome: united states 2007

ABSTRACT OBJECTIVE: Antenatal steroid use has been associated with reduction in the risk of neonatal mortality in meta-analyses of clinical trials. In 2007, a revised US birth certificate

offered information on antenatal steroid use in 22 states. The aim of this study was to review the association between antenatal steroid use and neonatal mortality by gestational age

categories for preterm infants (<37 weeks) for the United States for the year 2007. STUDY DESIGN: Data were obtained from the United States Linked Infant Birth and Death Certificate

Public Use Period file for the year 2007. Associations between antenatal steroid use and neonatal death were determined by logistic regression adjusting for potentially confounding

variables. RESULT: There were 245 453 preterm births and 4220 neonatal deaths available for analysis with complete data on antenatal steroid use. The highest prevalence for antenatal steroid

use among neonatal intensive care unit admissions (NICU) was 22% in the 26 to 28 week gestational age category, whereas the lowest prevalence was in the 34- to 36-week group at 7%.

Following adjustment for potentially confounding variables by logistic regression, the adjusted odds ratios (95% confidence interval) for neonatal mortality (antenatal steroid use versus

non-use) ranged from 0.56 (0.46 to 0.67) at 22 to 25 weeks; 0.66 (0.53 to 0.83) at 26 to 28 weeks; 0.69 (0.55 to 0.85) at 29 to 33 weeks and 0.69 (0.47 to 1.01) at 34 to 36 weeks.

CONCLUSION: These data are in accordance with meta-analytical data of randomized clinical trials and network reports on reduction of neonatal mortality with the use of antenatal steroids,

and provide support for the use of antenatal steroids for late preterm births. Access through your institution Buy or subscribe This is a preview of subscription content, access via your

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* Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS ASSOCIATION OF ANTENATAL STEROID ADMINISTRATION WITH NEONATAL

MORBIDITIES AMONG LATE PRETERM MULTIPLE GESTATION INFANTS Article 01 October 2024 LATE PRETERM ANTENATAL STEROID USE AND INFANT OUTCOMES IN A SINGLE CENTER Article 18 March 2024 ASSOCIATION

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ACKNOWLEDGEMENTS This analysis was presented in part at the Annual Meeting of the Pediatric Academic Societies in Denver, Colorado, 2 May, 20011. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS

* Department of Pediatrics, The University of Texas Medical Branch, Galveston, TX, USA M H Malloy Authors * M H Malloy View author publications You can also search for this author inPubMed 

Google Scholar CORRESPONDING AUTHOR Correspondence to M H Malloy. ETHICS DECLARATIONS COMPETING INTERESTS The author declares no conflict of interest. RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Malloy, M. Antenatal steroid use and neonatal outcome: United States 2007. _J Perinatol_ 32, 722–727 (2012).

https://doi.org/10.1038/jp.2012.22 Download citation * Received: 06 December 2011 * Revised: 13 February 2012 * Accepted: 21 February 2012 * Published: 22 March 2012 * Issue Date: September

2012 * DOI: https://doi.org/10.1038/jp.2012.22 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is

not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * antenatal steroids * neonatal mortality * preterm

infants