Β3-adrenoceptor function and long-term changes in body weight

ABSTRACT BACKGROUND: The endogenous factors contributing to long-term changes in body weight are not known but the regulation of energy metabolism by different beta-adrenoceptors (β1-AR,

β2-AR, β3-AR) or alpha-adrenoceptors (α2-AR) may play a role. METHODS: In a prospective study, we investigated β-AR and α2-AR subtype function in subcutaneous fat cells of 85 healthy,

non-obese women by using a standardized bioassay of lipolysis. Of these 73 were re-investigated on an average 10 years later to compare baseline function of β1-AR, β2-AR, β3-AR and α2-AR

with longitudinal weight changes. RESULTS: Weight change over time was normally distributed ranging from−4 kg/m2 to +6 kg/m2 in body mass index. Long-term changes in body weight correlated

inversely with β3-AR function at base line (_r_=0.5, _P_=0.001). Those with low β3−AR function gained weight, whereas the opposite was observed with those who had a high β3-AR function.

Nineteen percent of weight changes could be explained by β3-AR status. No relationship with weight changes was observed as regards the function of α2-AR, β1-AR or β2-AR function.

CONCLUSIONS: β3-ARs are important for long-term changes in body weight putting energy metabolism in adipose tissue in frontline among endogenous factors that regulate body weight in

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Eva Sjölin, Katarina Hertel and Britt-Marie Leionhufvud for their skillful technical assistance. This study was supported by grants from Swedish Research Council, Novo Nordisk Foundation,

Swedish Diabetes Foundation and Old Female Servant Foundation. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department for Endocrinology, Metabolism and Diabetes, Karolinska University

Hospital Huddinge, Stockholm, Sweden D Andersson, H Wahrenberg & P Löfgren * Department of Medicine, Karolinska Institutet, Stockholm, Sweden D Andersson, H Wahrenberg & P Löfgren

Authors * D Andersson View author publications You can also search for this author inPubMed Google Scholar * H Wahrenberg View author publications You can also search for this author

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PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Andersson, D., Wahrenberg, H. & Löfgren, P. β3-Adrenoceptor function and long-term changes in body weight. _Int

J Obes_ 33, 662–668 (2009). https://doi.org/10.1038/ijo.2009.54 Download citation * Received: 26 October 2008 * Revised: 25 February 2009 * Accepted: 07 March 2009 * Published: 14 April 2009

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terbutaline * dobutamine * CGP 12177