A recessive lethal super-suppressor mutation in yeast and other ψ phenomena

ARTICLE PDF REFERENCES * Brenner, S, Stretton, A O W, and Kaplan, S. 1966. Genetic Code: the “nonsense” triplets for chain termination and their suppression. _Nature_, 206, 994–998. Article

  Google Scholar  * Capecghi, M. 1967. Polypeptide chain termination _in vitro_: isolation of a release factor. _Proc natl Acad Sci (Wash)_, 58, 1144–1151. Article  Google Scholar  * Carbon,

J, and Curry, J B. 1969. Genetically and chemically derived missense suppressor transfer RNA's with altered enzymatic aminoacylation rates. _J molec Biol_, 38, 201–216. Article  Google

Scholar  * Cox, B S. 1965. _Ψ_, a cytoplasmic suppressor of super-suppressor in yeast. _Heredity_, 20, 505–521. Article  Google Scholar  * Cox, B S, and Bevan, E A. 1962. Aneuploidy in

yeast. _New Phytol_, 61, 342–355. Article  Google Scholar  * Gilmore, R A. 1966. Ph.D. Thesis, University of California, Berkeley. * Gilmore, R A. 1967. Super-suppressors in _Saccharomyces

cerevisiae_. _Genetics_, 56, 641–658. CAS  Google Scholar  * Gilmore, R A, and Mortimer, R K. 1966. Super-suppressor mutations in _Saccharomyces cerevisiae_. _J molec Biol_, 20, 307–311.

Article  CAS  Google Scholar  * Gilmore, R A, Stewart, J W, and Sherman, F. 1968. Amino-acid replacements resulting from super-suppression of a nonsense mutant of yeast. _Biochim Biohpys

Acta_, 161, 270–272. Article  CAS  Google Scholar  * Goodman, H M, Abelson, J, Landy, A, Brenner, S, and Smith, J D. 1968. Amber suppression: a nucleotide change in the anticodon of a

tyrosine transfer RNA. _Nature_, 217, 1019–1024. Article  CAS  Google Scholar  * Hawthorne, D C. 1969a. Identification of nonsense codons in y east. _J molec Biol_, 43, 71–75. Article  CAS 

Google Scholar  * Hawthorne, D C. 1969b. The selection of nonsense suppressors in yeast. _Mutation Res_, 7, 187–197. Article  CAS  Google Scholar  * Hawthorne, D C, and Mortimer, R K. 1960.

Chromosome mapping in _Saccharomyces_: centromere-linked genes. _Genetics_, 45, 1085–1110. CAS  Google Scholar  * Hawthorne, D C, and Mortimer, R K. 1963. Super-suppressors in yeast.

_Genetics_, 48, 617–620. CAS  Google Scholar  * Hawthorne, D C, and Mortimer, R K. 1968. Genetic mapping of nonsense suppressors in yeast. _Genetics_, 60, 735–742. CAS  Google Scholar  *

Hurst, D D, and Fogel, S. 1964. Mitotic recombination and heteroallelic repair in _Saccharomyces cerevisiae_. _Genetics_, 50, 435–458. CAS  Google Scholar  * Inge-Vegtomov, S G. 1965.

Suppressors of adenine requirement in yeast. _Genetika_, 2, 22–26. Google Scholar  * Johnston, J R, and Mortimer, R K. 1959. Use of snail digestive juice in isolation of yeast spore tetrads.

_J Bacteriol_, 78, 292. CAS  Google Scholar  * Milman, G, Goldstein, J, Scolnick, E, and Caskey, T. 1969. Peptide chain termination. III. Stimulation of _in vitro_ termination. _Proc natl

Acad Sci (Wash)_, 63, 183–190. Article  CAS  Google Scholar  * Mortimer, R K, and Hawthorne, D C. 1966. Genetic mapping in _Saccharomyces_. _Genetics_, 53, 165–173. CAS  Google Scholar  *

Ohlson, B M, Strigini, P F, and Begkwith, J R. 1968. Allelic amber and ochre suppressors. _J molec Biol_, 36, 209–218. Article  Google Scholar  * Person, S, and Osborne, M. 1968. The

conversion of amber suppression to ochre suppression. _Proc natl Acad Sci (Wash)_, 60, 1030–1037. Article  CAS  Google Scholar  * Schweizer, E, Mackechnie, C, and Halvorson, H O. 1969. The

redundancy of ribosomal and transfer RNA genes in _Saccharomyces cerevisiae_. _J molec Biol_, 40, 261–227. Article  CAS  Google Scholar  * Sgolnigk, E, Tompkins, R, Caskey, T, and Nirenberg,

M. 1968. Release factors differing in specificity for terminator codons. _Proc natl Acad Sci (Wash)_, 61, 768–774. Article  Google Scholar  * Sherman, F, Stewart, J W, Parker, J H,

Putterman, G J, Agrawal, B L, and Margoliash, E. 1970. On the relationship of gene structure and protein structure of iso-1-cytochrome _c_ from yeast. _Symp Society for Experimental

Biology_, 24, 85–107. CAS  Google Scholar  * Soll, L, and Berg, P. 1969. Recessive lethal nonsense suppressor in _Escherichia coli_ which inserts glutamine. _Nature_, 223, 1340–1342. Article

  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Botany School, South Parks Road, Oxford B S Cox Authors * B S Cox View author publications You can

also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Cox, B. A recessive lethal super-suppressor mutation

in yeast and other _ψ_ phenomena. _Heredity_ 26, 211–230 (1971). https://doi.org/10.1038/hdy.1971.28 Download citation * Received: 12 May 1970 * Issue Date: 01 April 1971 * DOI:

https://doi.org/10.1038/hdy.1971.28 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently

available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative