Pulsatile ocular blood flow in eyes with untreated choroidal melanoma

ABSTRACT _Purpose:_ To investigate the effect of choroidal melanoma on pulsatile ocular blood flow (POBF). _Methods:_ Seventeen patients (10 men and 7 women) with unilateral untreated

choroidal melanoma and 22 controls matched for age and sex were studied. Intraocular pressure (IOP), pulse amplitude (PA) and POBF were measured using the OBF Tonograph. In each patient,

mean inter-ocular differences were analysed using the paired _t_-test. The correlation coefficient between tumour thickness and POBF was calculated. To assess the variation of this

parameter, the coefficient of variation for three repeated readings was determined for healthy and affected eyes. _Results:_ In the control group, there was no significant difference between

eyes in any parameter. In patients with melanoma, there was no significant difference in IOP and PA between affected and unaffected eyes. Mean POBF was significantly higher in affected eyes

(1040 µl min−1) than unaffected eyes (876 µl min−1) (_p_ = 0.003). There was no correlation between tumour thickness and absolute POBF (_r_ = −0.24) or between tumour thickness and

inter-ocular difference in POBF between affected and unaffected eyes (_r_ = −0.17). Mean coefficient of variation of three repeated readings of POBF was 7.76% in healthy eyes and 8.97% in

afcted eyes. _Conclusions:_ These findings suggest a high tumour blood flow or a global increase in choroidal blood flow in the presence of melanoma. POBF measurement may be useful in the

clinical assessment of eyes with choroidal melanoma. SIMILAR CONTENT BEING VIEWED BY OTHERS EFFECTS OF PHYSIOLOGICAL FLUCTUATIONS ON THE ESTIMATION OF VASCULAR FLOW IN EYES WITH IDIOPATHIC

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references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Liverpool Y C Yang, D Kent, C H Fenerty, A S Kosmin & B E Damato Authors * Y C Yang View author publications You can also search

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ocular blood flow in eyes with untreated choroidal melanoma. _Eye_ 11, 331–334 (1997). https://doi.org/10.1038/eye.1997.70 Download citation * Issue Date: 01 May 1997 * DOI:

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available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * Ocular * Blood flow * Pulsatile * Choroidal * Melanoma