Neural circuit underlying asthma reinforces the lung’s role as a sensory organ

Neural circuit underlying asthma reinforces the lung’s role as a sensory organ


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RESEARCH BRIEFINGS 07 August 2024 Neural circuit underlying asthma reinforces the lung’s role as a sensory organ Molecular, anatomical and functional evidence point to a multi-nodal neural


circuit that senses allergenic particles in inhaled air and induces exaggerated airway constriction, a hallmark of asthma. This is the first description of a full circuit that starts in the


lung and returns to control lung function. Twitter Facebook Email Access through your institution Buy or subscribe This is a summary of: Su, Y. et al. Brainstem Dbh+ neurons control


allergen-induced airway hyperreactivity. Nature 631, 601–609 (2024).

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doi: https://doi.org/10.1038/d41586-024-02564-6


Figure 1 is published under a CC BY 4.0 licence.


References Chen, W. G. et al. Trends Neurosci. 44, 3–16 (2021).


Article  PubMed  Google Scholar 


Su, Y. et al. Am. J. Physiol. Lung Cell Mol. Physiol. 322, L50–L63 (2022).


Article  PubMed  Google Scholar 


Taylor-Clark, T. E. & Undem, B. J. Handb. Clin. Neurol. 188, 373–391 (2022).


Article  PubMed  Google Scholar 


Pincus, A. B., Adhikary, S., Lebold, K. M., Fryer, A. D. & Jacoby, D. B. Am. J. Resp. Cell. Mol. Biol. 62, 423–429 (2020).


Article  Google Scholar 


Sui, P. et al. Science 360, eaan8546 (2018).


Article  PubMed  Google Scholar 


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