Inner membrane turns inside out to exit mitochondrial organelles

Inner membrane turns inside out to exit mitochondrial organelles


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NEWS AND VIEWS 21 August 2024 Inner membrane turns inside out to exit mitochondrial organelles How do mitochondrial organelles remove damaged parts of inner membrane for recycling in the


cytoplasm? The discovery of an exit route that flips inner membrane outside the organelle provides some answers. By David Pla-Martín ORCID: http://orcid.org/0000-0002-5189-07230 & Andreas S.


Reichert ORCID: http://orcid.org/0000-0001-9340-31131 David Pla-Martín David Pla-Martín is at the Institute of Biochemistry and Molecular Biology I, Medical Faculty, University Hospital


Düsseldorf, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.


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Andreas S. Reichert Andreas S. Reichert is at the Institute of Biochemistry and Molecular Biology I, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf,


40225 Düsseldorf, Germany.


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Twitter Facebook Email Access through your institution Buy or subscribe Organelles such as mitochondria use a variety of mechanisms to recycle their components. Writing in Nature, Prashar et


al.1 report a surprising new twist in how these events can occur.

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Nature 632, 987-988 (2024)


doi: https://doi.org/10.1038/d41586-024-02528-w


References Prashar, A. et al. Nature 632, 1110–1117 (2024).


Article  Google Scholar 


Picard, M. & Shirihai, O. S. Cell Metab. 34, 1620–1653 (2022).


Article  PubMed  Google Scholar 


Suomalainen, A. & Nunnari, J. Cell 187, 2601–2627 (2024).


Article  PubMed  Google Scholar 


Priault, M. et al. Cell Death Differ. 12, 1613–1621 (2005).


Article  PubMed  Google Scholar 


Lemasters, J. J. Rejuvenation Res. 8, 3–5 (2005).


Article  PubMed  Google Scholar 


Narendra, D., Tanaka, A., Suen, D.-F. & Youle, R. J. J. Cell Biol. 183, 795–803 (2008).


Article  PubMed  Google Scholar 


Kitada, T. et al. Nature 392, 605–608 (1998).


Article  PubMed  Google Scholar 


Valente, E. M. et al. Am. J. Hum. Genet. 68, 895–900 (2001).


Article  PubMed  Google Scholar 


Abudu, Y. P. et al. J. Cell Biol. 220, e202009092 (2021).


Article  PubMed  Google Scholar 


Hammerling, B. C. et al. Nature Commun. 8, 14050 (2017).


Article  PubMed  Google Scholar 


Sen, A. et al. Nature Commun. 13, 6704 (2022).


Article  PubMed  Google Scholar 


Sugiura, A., McLelland, G.-L., Fon, E. A. & McBride, H. M. EMBO J. 33, 2142–2156 (2014).


Article  PubMed  Google Scholar 


Hughes, A. L., Hughes, C. E., Henderson, K. A., Yazvenko, N. & Gottschling, D. E. eLife 5, e13943 (2016).


Article  PubMed  Google Scholar 


Ma, X. et al. Cell Rep. 42, 113291 (2023).


Article  PubMed  Google Scholar 


McArthur, K. et al. Science 359, eaao6047 (2018).


Article  PubMed  Google Scholar 


Tábara, L. C. et al. Cell 187, 3619–3637 (2024).


Article  PubMed  Google Scholar 


Kondadi, A. K. et al. EMBO Rep. 21, e49776 (2020).


Article  PubMed  Google Scholar 


Wolf, D. M. et al. EMBO J. 38, e101056 (2019).


Article  PubMed  Google Scholar 


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The authors declare no competing interests.


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