Scientists edit the genes of gut bacteria in living mice

Scientists edit the genes of gut bacteria in living mice


Play all audios:

Loading...

NEWS 10 July 2024 Correction 12 July 2024 Scientists edit the genes of gut bacteria in living mice A ‘base editor’ successfully modified a gene in more than 90% of Escherichia coli bacteria


without unwanted side effects. By Gemma Conroy Gemma Conroy View author publications You can also search for this author in PubMed  Google Scholar


Twitter Facebook Email Access through your institution Buy or subscribe Scientists have designed a gene-editing tool that can modify bacterial populations in the gut microbiome of living


mice1.

Access options Access through your institution Additional access options: Log in Learn about institutional subscriptions Read our FAQs Contact customer support


Nature 631, 720-721 (2024)


doi: https://doi.org/10.1038/d41586-024-02238-3


Updates & Corrections Correction 12 July 2024: A previous version of this story incorrectly described the effect of the base editor in the bacteria.


References Brödel, A. K. et al. Nature https://doi.org/10.1038/s41586-024-07681-w (2024).


Article  Google Scholar 


Gencay, Y. M. et al. Nature Biotechnol. 42, 265–274 (2024).


Article  PubMed  Google Scholar 


Lam, K. N. et al. Cell Rep. 37, 109930 (2021).


Article  PubMed  Google Scholar 


Selle, K. et al. mBio 11, e00019-20 (2020).


PubMed  Google Scholar 


Download references


Reprints and permissions


Related Articles CRISPR 2.0: a new wave of gene editors heads for clinical trials


First trial of ‘base editing’ in humans lowers cholesterol — but raises safety concerns


Subjects Gene therapy Genomics Latest on: Gene therapy In vivo haemopoietic stem cell gene therapy enabled by postnatal trafficking


Article 28 MAY 25


World first: ultra-powerful CRISPR treatment trialled in a person


News 19 MAY 25


Powerful CRISPR system inserts whole gene into human DNA


News 15 MAY 25


Genomics Genomics pioneer fired from firm he founded: ‘It was not easy to domesticate me’


News Q&A 04 JUN 25


Black Death bacterium has become less lethal after genetic tweak


News 29 MAY 25


This ancient pathogen became deadlier when humans started wearing wool


News 22 MAY 25


Jobs Post-Doctoral Fellowship in Regenerative Biology and Medicine (Lab of. Dr. Yuval Rinkevich) Discovery of cellular and molecular mechanisms of tissue repair and regeneration.


Beijing, China


The Chinese Institutes for Medical Research (CIMR), Beijing


Tenure-track Assistant Professor towards Associate Professor in the field of metabolic diseases UNIL is a leading international teaching and research institution, with over 5,000 employees


and 15,500 students split between its Dorigny campus, ...


Lausanne, Canton of Vaud (CH)


University of Lausanne (UNIL)


Associate or Senior Editor (Nature Structural & Molecular Biology and Nature Communications) Job Title: Associate or Senior Editor (Nature Structural & Molecular Biology and Nature


Communications)  Location: New York, Shanghai, Beijing, Mad...


New York City, New York (US)


Springer Nature Ltd


Postdoctoral Associate – Nima Sharifi Laboratory The Nima Sharifi Laboratory is seeking to recruit outstanding postdoctoral associates with a primary interest in the fundamental mechanisms


of huma...


Miami, Florida (US)


University of Miami Desai Sethi Urology Institute


Associate or Senior Editor, BMC Medicine Job Title: Associate or Senior Editor, BMC Medicine Location(s): Shanghai – Hybrid working model Application Deadline: June 25th, 2025   About


Spri...


Shanghai – Hybrid working model


Springer Nature Ltd