Mechanisms mediating neuroinflammation in ms

* IN BRIEF * 12 January 2022 By * Sarah Crunkhorn * Sarah Crunkhorn Pro-inflammatory T cells in the CNS drive multiple sclerosis (MS), but the mechanisms regulating these cells remain

incompletely understood. In a mouse model of MS, Grigg et al. identify a subset of group 3 innate lymphoid cells (ILC3s) that migrate from the circulation to the CNS. In contrast to

peripheral tissue-resident ILC3s, which promote T cell tolerance and suppress inflammation, these ILC3s mature in the CNS to function as antigen-presenting cells (expressing MHCII and

co-stimulatory molecules) that activate myelin-specific T cells and promote CNS inflammation. Loss of MHCII on these ILC3s reduced myelin-specific T cells, decreased immune cell infiltration

and prevented demyelinating disease in mice. ACCESS OPTIONS Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $32.99 / 30 days

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https://doi.org/10.1038/d41573-022-00007-3_ REFERENCES