A review of rgd-functionalized nonviral gene delivery vectors for cancer therapy

ABSTRACT The development of effective treatments that enable many patients suffering from cancer to be successfully cured is highly demanded. Angiogenesis, which is a process for the

formation of new capillary blood vessels, has a crucial role in solid tumor progression and the development of metastasis. Antiangiogenic therapy designed to prevent tumor angiogenesis,

thereby arresting the growth or spread of tumors, has emerged as a non-invasive and safe option for cancer treatment. Due to the fact that integrin receptors are overexpressed on the surface

of angiogenic endothelial cells, various strategies have been made to develop targeted delivery systems for cancer gene therapy utilizing integrin-targeting peptides with an exposed

arginine–glycine–aspartate (RGD) sequence. The aim of this review is to summarize the progress and prospect of RGD-functionalized nonviral vectors toward targeted delivery of genetic

materials in order to achieve an efficient therapeutic outcome for cancer gene therapy, including antiangiogenic therapy. Access through your institution Buy or subscribe This is a preview

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STRATEGIES AND TARGETS IN CANCER GENE THERAPY Article 15 April 2021 GENE THERAPY WITH ENTEROVIRUS 3 C PROTEASE: A PROMISING STRATEGY FOR VARIOUS SOLID TUMORS Article Open access 08 May 2025

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Health technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A111803). We thank Dr Matthew Hurley for the proofreading of the manuscript. AUTHOR INFORMATION

AUTHORS AND AFFILIATIONS * Department of Chemistry, BK21 Program, Polymer Research Institute, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea J Park, K

Singha, S Son, J Kim, R Namgung & W J Kim * Department of Bioengineering, College of Engineering, Hanyang University, Seoul, Republic of Korea C-O Yun Authors * J Park View author

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conflict of interest. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Park, J., Singha, K., Son, S. _et al._ A review of RGD-functionalized nonviral gene

delivery vectors for cancer therapy. _Cancer Gene Ther_ 19, 741–748 (2012). https://doi.org/10.1038/cgt.2012.64 Download citation * Received: 22 May 2012 * Revised: 27 August 2012 *

Accepted: 27 August 2012 * Published: 28 September 2012 * Issue Date: November 2012 * DOI: https://doi.org/10.1038/cgt.2012.64 SHARE THIS ARTICLE Anyone you share the following link with

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content-sharing initiative KEYWORDS * RGD peptide * integrin * angiogenesis * nonviral vectors