Type i collagen degradation product (ictp) gives information about the nature of bone metastases and has prognostic value in prostate cancer

ABSTRACT Although osteosclerotic bone metastases are characteristic of prostate cancer, mixed metastases with a lytic component are not uncommon. Type I collagen is synthesised by

osteoblasts and accounts for about 90% of the organic matrix of bone. We have used new specific immunoassays for PICP (carboxy-terminal propeptide of type I procollagen) and ICTP

(cross-linked carboxy-terminal telopeptide of type I collagen) which allow simultaneous assessment of the synthesis and degradation of type I collagen respectively. Forty patients with bone

metastases due to prostate cancer at the time of diagnosis were investigated with these methods. Twenty-three of them had sclerotic (S) and 17 had mixed metastases with sclerotic and lytic

components (S + L) as assessed by radiographs. The concentrations of PICP and ICTP in serum as well as the activity of alkaline phosphatase (AP) were increased in all patients of the S + L

group, who had more aggressive bone disease and a shorter survival than the S group (P < 0.017). The ICTP level was above the reference range in half of the patients in the S group,

whereas the PICP and AP levels were elevated in 35%. Of the bone markers, only ICTP was of prognostic significance (P < .05). We conclude that ICTP and PICP give information about the

type and activity of the skeletal metastases. In addition, ICTP predicts prognosis. Access through your institution Buy or subscribe This is a preview of subscription content, access via

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OF SWOG S1216, A PHASE III TRIAL OF ANDROGEN DEPRIVATION WITH OR WITHOUT ORTERONEL Article 29 February 2024 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Urology, University of

Tampere, Finland T Kylmälä Authors * T Kylmälä View author publications You can also search for this author inPubMed Google Scholar * TLJ Tammela View author publications You can also search

for this author inPubMed Google Scholar * L Risteli View author publications You can also search for this author inPubMed Google Scholar * J Risteli View author publications You can also

search for this author inPubMed Google Scholar * M Kontturi View author publications You can also search for this author inPubMed Google Scholar * I Elomaa View author publications You can

also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kylmälä, T., Tammela, T., Risteli, L. _et al._ Type I

collagen degradation product (ICTP) gives information about the nature of bone metastases and has prognostic value in prostate cancer. _Br J Cancer_ 71, 1061–1064 (1995).

https://doi.org/10.1038/bjc.1995.204 Download citation * Issue Date: 01 May 1995 * DOI: https://doi.org/10.1038/bjc.1995.204 SHARE THIS ARTICLE Anyone you share the following link with will

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