9-alkyl anthracyclines. Absence of cross-resistance to adriamycin in human and murine cell cultures

ABSTRACT Four cell lines of human (CCRF CEM and U266BL) or murine (L1210 and P388D1) origin, resistant to the anthracycline antibiotic Adriamycin (doxorubicin) were selected _in vitro_ from

cultured cells by serial passage in the presence of Adriamycin. The resistant sublines were also cross-resistant to Mitoxantrone, 4'-epi Adriamycin and a number of novel anthracyclines

including 4'-deoxy and 4'-methoxy analogues. However, a series of 9-alkyl substituted 4-demethoxyanthracyclines retained full activity against all the resistant sublines as did

Aclacinomycin A. These results suggest that 9-alkyl substitution of 4-demethoxy-anthracyclines is an important determinant of activity against Adriamycin-resistant cell lines _in vitro_.

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CHK1 ACTIVATION AND SHARES THE MECHANISM WITH INHIBITORS OF DHODH AND PYRIMIDINE SYNTHESIS Article Open access 05 July 2022 Authors * C A Scott View author publications You can also search

for this author inPubMed Google Scholar * D Westmacott View author publications You can also search for this author inPubMed Google Scholar * M J Broadhurst View author publications You can

also search for this author inPubMed Google Scholar * G J Thomas View author publications You can also search for this author inPubMed Google Scholar * M J Hall View author publications You

can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Scott, C., Westmacott, D., Broadhurst, M. _et

al._ 9-Alkyl anthracyclines. Absence of cross-resistance to adriamycin in human and murine cell cultures. _Br J Cancer_ 53, 595–600 (1986). https://doi.org/10.1038/bjc.1986.101 Download

citation * Issue Date: 01 May 1986 * DOI: https://doi.org/10.1038/bjc.1986.101 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable

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