Comparison of mesna with forced diuresis to prevent cyclophosphamide induced haemorrhagic cystitis in marrow transplantation: a prospective randomised study

ABSTRACT A prospective randomised study was carried out to compare the effect of mesna (2-mercaptoethane sulphonate sodium) with that of forced diuresis in preventing cyclophosphamide

induced haemorrhagic cystitis in marrow transplant recipients. Sixty-one consecutive BMT recipients were randomised for treatment with forced diuresis or mesna. The incidence of macroscopic

haematuria was significantly lower in the mesna treated group (chi 2 = 4.03, P less than 0.05). No specific side effects of mesna were detected. The lymphopenia induced by cyclophosphamide

in the aplastic recipients was similar in the mesna and forced diuresis groups suggesting that mesna has no effect on the lymphocytotoxic activity of cyclophosphamide, although 6 out of 7

episodes of graft failure documented in the study occurred in mesna treated patients. As a result of this study our present policy is to use mesna in all BMT recipients but to continue

careful documentation of the incidence of graft failure. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS

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institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS USE OF HIGH-DOSE MESNA AND HYPERHYDRATION LEADS TO LOWER INCIDENCE OF

HEMORRHAGIC CYSTITIS AFTER POSTTRANSPLANT CYCLOPHOSPHAMIDE-BASED ALLOGENEIC TRANSPLANTATION Article 09 June 2021 CLINICAL EFFICACY OF UREA TREATMENT IN SYNDROME OF INAPPROPRIATE ANTIDIURETIC

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NEPHROTOXICITY Article Open access 07 May 2024 Authors * J M Hows View author publications You can also search for this author inPubMed Google Scholar * A Mehta View author publications You

can also search for this author inPubMed Google Scholar * L Ward View author publications You can also search for this author inPubMed Google Scholar * K Woods View author publications You

can also search for this author inPubMed Google Scholar * R Perez View author publications You can also search for this author inPubMed Google Scholar * M Y Gordon View author publications

You can also search for this author inPubMed Google Scholar * E C Gordon-Smith View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS

Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hows, J., Mehta, A., Ward, L. _et al._ Comparison of mesna with forced diuresis to prevent cyclophosphamide induced haemorrhagic

cystitis in marrow transplantation: a prospective randomised study. _Br J Cancer_ 50, 753–756 (1984). https://doi.org/10.1038/bjc.1984.252 Download citation * Issue Date: 01 December 1984 *

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