Growth of human colonic adenocarcinoma and development of serum cea in athymic mice. I: strict correlation of tumour size and mass with serum cea concentration during logarithmic growth

ABSTRACT The secretion of CEA into the blood of athymic mice was studied with 4 sublines of human colonic adenocarcinoma cell lines, HT 29 and SLu. Growth curves based on tumour volume

(caliper measurements) or tumour mass (weight) correlated with a concomitant increase of serum CEA during the logarithmic growth phase, but showed a marked dissociation when the growth rate

slowed down. In the logarithmic growth phase doubling times between 2 and 6 days were calculated and about 6-7 doubling times passed until the shift in the growth rate was observed,

independently of the sublines transplanted. Constant increases of CEA between 0.03 and 0.45 microgram/l serum per mm3 increase of tumour volume, depending on the sublines, were recorded

during the logarithmic growth phase. Sublines releasing high amounts of CEA _in vitro_ (cell culture) retained this characteristic _in vivo_. Correlation between tumour volume and tumour

mass or serum CEA showed correlation coefficients of 0.820-0.977 during the logarithmic growth phase. Access through your institution Buy or subscribe This is a preview of subscription

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OF CC531 RAT COLORECTAL CANCER CELLS BOTH IN VITRO AND IN VIVO Article Open access 08 March 2021 GASTRIC GHRELIN CELLS IN OBESE PATIENTS ARE HYPERACTIVE Article 23 November 2020 EXPRESSION

OF G PROTEIN-COUPLED RECEPTOR GPR19 IN NORMAL AND NEOPLASTIC HUMAN TISSUES Article Open access 03 November 2023 Authors * H J Staab View author publications You can also search for this

author inPubMed Google Scholar * F A Anderer View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS

ARTICLE CITE THIS ARTICLE Staab, H., Anderer, F. Growth of human colonic adenocarcinoma and development of serum CEA in athymic mice. I: strict correlation of tumour size and mass with serum

CEA concentration during logarithmic growth. _Br J Cancer_ 46, 841–847 (1982). https://doi.org/10.1038/bjc.1982.293 Download citation * Issue Date: 01 December 1982 * DOI:

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