Mesotheliomata in rats after inoculation with asbestos and other materials

ABSTRACT Four experiments in which SPF Wistar rats were inoculated intrapleurally with asbestos or other materials are described. Mesotheliomata were observed in a considerable proportion of

animals with all the samples of asbestos used and with a sample of brucite. A few were produced with synthetic aluminium silicate fibres and single ones with barium sulphate, glass powder

and aluminium oxide. The risk of developing a mesothelioma at a given time after injection was approximately proportional to the dose. Of the UICC standard reference samples, crocidolite was

the most carcinogenic and removal of the oils by benzene extraction did not alter the carcinogenicity of these samples. Chemical properties also seem unlikely to be the main factor

producing mesotheliomata but the results support the hypothesis that the finer fibres are the more carcinogenic, and this is additional to the known aerodynamic advantage which the finer

fibres have in penetrating to the periphery of the lung. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS

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BRITISH NUCLEAR TESTS 1952–1967 Article Open access 14 November 2023 NTCU INDUCED PRE-MALIGNANT AND MALIGNANT STAGES OF LUNG SQUAMOUS CELL CARCINOMA IN MICE MODEL Article Open access 18

November 2021 INTRAPERITONEAL COLLAGENASE AS A NOVEL THERAPEUTIC APPROACH IN AN EXPERIMENTAL MODEL OF COLORECTAL PERITONEAL CARCINOMATOSIS Article Open access 12 January 2021 Authors * J C

Wagner View author publications You can also search for this author inPubMed Google Scholar * G Berry View author publications You can also search for this author inPubMed Google Scholar * V

Timbrell View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Wagner,

J., Berry, G. & Timbrell, V. Mesotheliomata in Rats after Inoculation with Asbestos and Other Materials. _Br J Cancer_ 28, 173–185 (1973). https://doi.org/10.1038/bjc.1973.134 Download

citation * Issue Date: 01 August 1973 * DOI: https://doi.org/10.1038/bjc.1973.134 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable

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