Influence of vascular endothelial growth factor single nucleotide polymorphisms on tumour development in cutaneous malignant melanoma

ABSTRACT Vascular endothelial growth factor (VEGF) is a potent regulator of vasculogenesis and tumour angiogenesis. We have investigated whether the VEGF −2578, −1154, +405 and +936 SNPs and

associated haplotypes confer susceptibility to and/or influence prognosis in cutaneous malignant melanoma (CMM) skin cancer. A total of 152 CMM patients and 266 controls were genotyped for

VEGF promoter SNPs by ARMS-PCR. Strong linkage disequilibrium between the −2578, −1154 and +405 SNPs was detected (association, ρ = 0.488–0.965), but not between these SNPs and SNP +936

(association, ρ = 0.004–0.130). No SNPs or three SNP haplotypes (−2578, −1154, +405) were significantly associated with CMM, although a number of non-significant trends were observed.

However, the VEGF −1154 AA genotype and −2578, −1154, +405 CAC haplotype were both significantly associated with less advanced (Stage 1) disease (P = 0.03). In addition, the VEGF −1154 AA

genotype was associated with thinner primary vertical growth phase tumours (P = 0.002), while VEGF −1154 GG was associated with thicker primary tumours (P = 0.02). These preliminary results

indicate that VEGF genotype may influence tumour growth in CMM, possibly via the effects of differential VEGF expression on tumour angiogenesis. Access through your institution Buy or

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VIEWED BY OTHERS INHERITED VARIATIONS IN HUMAN PIGMENTATION-RELATED GENES MODULATE CUTANEOUS MELANOMA RISK AND CLINICOPATHOLOGICAL FEATURES IN BRAZILIAN POPULATION Article Open access 22

July 2020 GENETIC VARIANTS FOR SMOKING BEHAVIOUR AND RISK OF SKIN CANCER Article Open access 06 October 2023 PRE-DIAGNOSTIC DNA METHYLATION IN BLOOD LEUCOCYTES IN CUTANEOUS MELANOMA; A

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Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Human Genetics, University of Southampton, Southampton, UK W M Howell, S J Turner & A

Collins * Histocompatibility and Immunogenetics Laboratory, Southampton General Hospital, Southampton, UK W M Howell * Department of Cellular Pathology, Southampton General Hospital,

Southampton, UK A C Bateman & J M Theaker Authors * W M Howell View author publications You can also search for this author inPubMed Google Scholar * A C Bateman View author publications

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publications You can also search for this author inPubMed Google Scholar * J M Theaker View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING

AUTHOR Correspondence to W M Howell. ADDITIONAL INFORMATION This work was supported by a grant from the Association for International Cancer Research, St Andrews, Scotland (No. 99–121)

RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Howell, W., Bateman, A., Turner, S. _et al._ Influence of vascular endothelial growth factor single

nucleotide polymorphisms on tumour development in cutaneous malignant melanoma. _Genes Immun_ 3, 229–232 (2002). https://doi.org/10.1038/sj.gene.6363851 Download citation * Received: 23

August 2001 * Revised: 27 December 2001 * Accepted: 03 January 2002 * Published: 12 June 2002 * Issue Date: 01 June 2002 * DOI: https://doi.org/10.1038/sj.gene.6363851 SHARE THIS ARTICLE

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by the Springer Nature SharedIt content-sharing initiative KEYWORDS * VEGF * SNPs * angiogenesis * malignant melanoma * cancer