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Access through your institution Buy or subscribe A GENETICIST WONDERS WHAT IT TAKES TO PROVE CAUSALITY. In the post-genomic era, we are increasingly confronted by a torrent of variation

data, originating from gene sequence, copy number and methylation patterns. To complicate matters further, I anticipate that a notable fraction of variation among individuals will be found

to be relatively rare events. This would severely hamper our ability to implement statistical methods to associate variants with disease pathogenesis. This is a preview of subscription

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ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Johns Hopkins University,

Baltimore, Maryland Nicholas Katsanis Authors * Nicholas Katsanis View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Katsanis, N. Journal club. _Nature_ 451, 503 (2008). https://doi.org/10.1038/451503a Download citation * Published: 30 January 2008 * Issue

Date: 31 January 2008 * DOI: https://doi.org/10.1038/451503a SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a

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