Association between prodh and schizophrenia is not confirmed

Access through your institution Buy or subscribe SIR – It has recently been reported that genetic variants of proline dehydrogenase (PRODH) increase susceptibility to schizophrenia.1 This is

of interest since PRODH maps within the velo-cardio-facial syndrome (VCFS) region of 22q11, deletion of which is one of the strongest known risk factors for schizophrenia.2 We have examined

this claim using two samples each with high power (>99%) to detect the effects reported. Our data suggest that genetic variation at PRODH is unlikely to be associated with even modestly

increased risk of schizophrenia, and that the earlier report is the result of chance. Liu _et al_1 reported association between various permutations of SNPs and haplotypes constructed from

markers at positions 1766, 1945, and 2026 of PRODH in a small sample (_n_=107) of European-American schizophrenic proband–parent trios, in a second sample of 26 trios where the proband had a

childhood onset illness, and in a third small sample of 109 adult Afrikaners and 75 controls. Their analysis suggested an association between schizophrenia and a ‘221’ haplotype at three

loci 1766/1945/2026, defined by alleles G, T, and C, respectively, and this effect was strongest for disease of early onset. This is a preview of subscription content, access via your

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article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in

* Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Liu H _et al_. _Proc Natl Acad Sci_ 2002; 99: 3717–3722. * Murphy KC, Jones LA, Owen MJ .

_Schizophr Res_ 2000; 41: 29. * Anney RJ _et al_. _Mol Psychiatry_ 2002; 7: 493–502 (1359–4184). Article  CAS  Google Scholar  * Xie X, Ott J . _Am J Hum Genet_ 1993; 53: 1107. * Zhao JH,

Curtis D, Sham PC . _Hum Hered_ 2000; 50: 133–139. * Sham PC, Curtis D . _Ann Hum Genet_ 1995; 59: 323–336. * Murphy KC, Jones LA, Owen MJ . _Arch Gen Psychiatry_ 1999; 56: 940–945. Article

  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff,

UK H J Williams, N Williams, G Spurlock, N Norton, D Ivanov, A Preece, S Jones, S Zammit, A Thapar, K C Murphy, G Kirov, M J Owen & M C O'Donovan * Department of Clinical Research,

Crichton Royal Hospital, Dumfries, UK R G McCreadie & V Sharkey * Medical University Sofia, Medical Genetics, Sofia, Bulgaria I Nikolov & I Kehaiov Authors * H J Williams View author

publications You can also search for this author inPubMed Google Scholar * N Williams View author publications You can also search for this author inPubMed Google Scholar * G Spurlock View

author publications You can also search for this author inPubMed Google Scholar * N Norton View author publications You can also search for this author inPubMed Google Scholar * D Ivanov

View author publications You can also search for this author inPubMed Google Scholar * R G McCreadie View author publications You can also search for this author inPubMed Google Scholar * A

Preece View author publications You can also search for this author inPubMed Google Scholar * V Sharkey View author publications You can also search for this author inPubMed Google Scholar *

S Jones View author publications You can also search for this author inPubMed Google Scholar * S Zammit View author publications You can also search for this author inPubMed Google Scholar

* I Nikolov View author publications You can also search for this author inPubMed Google Scholar * I Kehaiov View author publications You can also search for this author inPubMed Google

Scholar * A Thapar View author publications You can also search for this author inPubMed Google Scholar * K C Murphy View author publications You can also search for this author inPubMed 

Google Scholar * G Kirov View author publications You can also search for this author inPubMed Google Scholar * M J Owen View author publications You can also search for this author inPubMed

 Google Scholar * M C O'Donovan View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to M C O'Donovan.

ADDITIONAL INFORMATION Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS

ARTICLE CITE THIS ARTICLE Williams, H., Williams, N., Spurlock, G. _et al._ Association between PRODH and schizophrenia is not confirmed. _Mol Psychiatry_ 8, 644–645 (2003).

https://doi.org/10.1038/sj.mp.4001276 Download citation * Published: 22 July 2003 * Issue Date: 01 July 2003 * DOI: https://doi.org/10.1038/sj.mp.4001276 SHARE THIS ARTICLE Anyone you share

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