Long-lasting enhancement of nmda receptor-mediated synaptic transmission by metabotropic glutamate receptor activation

ABSTRACT SYNAPTIC transmission mediated by the _N_-methyl-D-aspartate (NMDA) glutamate receptor plays a key role in a range of plastic processes in the nervous system. These include

long-term potentiation of synaptic transmission mediated by the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor, neuronal development, excitotoxicity and certain learning

tasks1,2. Recently, long-term potentiation of NMDA receptor-mediated synaptic transmission was found to occur following high-frequency (tetanic) stimulation via an unknown mechanism3–7. We

show here that activation of metabotropic glutamate (mGlu) receptors by neurally released transmitter underlies this type of long-term potentiation. The whole-cell patch-clamp technique in

the 'thick' slice of the rat dentate gyrus was used to measure NMDA receptor-mediated excitatory postsynaptic currents. We have found that mGlu receptor activation by a selective

agonist produced a long-lasting enhancement which was mutually exclusive with long-term potentiation of these NMDA currents. Moreover, both forms of potentiation were greatly reduced by the

mGlu receptor antagonists L-2-amino-3-phosphonopropionate and (_R,S_)-α-methy 1-4-carboxyphenylglycine. Access through your institution Buy or subscribe This is a preview of subscription

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TIMING-DEPENDENT PLASTICITY DURING HIPPOCAMPAL DEVELOPMENT Article Open access 01 September 2020 MECHANISM UNDERLYING HIPPOCAMPAL LONG-TERM POTENTIATION AND DEPRESSION BASED ON COMPETITION

BETWEEN ENDOCYTOSIS AND EXOCYTOSIS OF AMPA RECEPTORS Article Open access 07 September 2020 A CRITICAL PERIOD FOR LEARNING AND PLASTIC CHANGES AT HIPPOCAMPAL CA1 SYNAPSES Article Open access

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Download references AUTHOR INFORMATION Author notes * John J. O'Connor Present address: Department of Human Anatomy and Physiology, University College Dublin, Earlsford Terrace, Dublin,

2, Ireland * Michael J. Rowan: To whom correspondence should be addressed. AUTHORS AND AFFILIATIONS * Department of Pharmacology and Therapeutics, John J. O'Connor & Michael J.

Rowan * Department of Physiology, Trinity College, Dublin, 2, Ireland Roger Anwyl Authors * John J. O'Connor View author publications You can also search for this author inPubMed Google

Scholar * Michael J. Rowan View author publications You can also search for this author inPubMed Google Scholar * Roger Anwyl View author publications You can also search for this author

inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE O'Connor, J., Rowan, M. & Anwyl, R. Long-lasting enhancement of NMDA

receptor-mediated synaptic transmission by metabotropic glutamate receptor activation. _Nature_ 367, 557–559 (1994). https://doi.org/10.1038/367557a0 Download citation * Received: 17 May

1993 * Accepted: 03 December 1993 * Issue Date: 10 February 1994 * DOI: https://doi.org/10.1038/367557a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this

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