Murderous hairpins | Nature Reviews Cancer

Access through your institution Buy or subscribe The normal function of the tumour suppressor p53 is to prevent cell multiplication and promote apoptosis. However, p53 is inactivated in most

types of human cancer, which allows cancerous cells to survive. Raj and colleagues infected cell lines — that were either null or wild type for p53 — with AAV, and used flow cytometry to

assess DNA content and cell fate. The p53 wild-type cells arrested briefly at the G2 phase, then re-entered the cell cycle after several days, whereas those that lacked p53 activity

underwent apoptosis. This effect could also be seen in tumours in nude mice that were induced by injection with p53−/− or p53+/+ cells: AAV reduced the incidence of p53−/− tumours by 17%

compared with controls, and caused established tumours to regress. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution

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Contact customer support REFERENCES * ORIGINAL RESEARCH PAPER Raj, K., Ogston, P. and Beard, P. Virus-mediated killing of cells that lack p53. _Nature_ 412, 914–916 (2001) Article  CAS 

Google Scholar  * FURTHER READING Vogelstein, B. and Kinzler, K. W. Achilles' heel of cancer? _Nature_ 412, 865–866 (2001) Article  CAS  Google Scholar  Download references Authors *

Sandra Clark View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Clark,

S. Murderous hairpins. _Nat Rev Cancer_ 1, 5 (2001). https://doi.org/10.1038/35094049 Download citation * Issue Date: 01 October 2001 * DOI: https://doi.org/10.1038/35094049 SHARE THIS

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