Role of self-peptides in positively selecting the t-cell repertoire

ABSTRACT THE fate of an immature thymocyte is determined by the specificity of its αβ T-cell receptor. Only cells expressing receptors that interact with sufficient affinity with major

histocompatibility complex (MHC) molecules expressed on thymus epithelial cells are positively selected and go on to mature and seed the peripheral lymphoid organs1–4. The H–2Kb class-I MHC

molecule positively selects for the maturation of cytotoxic ¤ lymphocytes that will respond in the periphery to H–2Kb cells presenting a foreign peptide. We have now analysed the ability of

variant H–2Kb molecules to positively select T-cells that respond to H–2Kb with ovalbumin. Our results indicate that self-peptides, presented in the groove of the class-I molecule on thymus

epithelial cells, are critically involved in positive selection of the T-cell repertoire. Furthermore, the ability of four different H–2Kb variants to select this response in the thymus

correlates with their ability to present the ovalbumin peptide, indicating that a self-peptide mimic of the foreign peptide could be involved in positive selection. Access through your

institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 51 print

issues and online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to

local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT

BEING VIEWED BY OTHERS A GUIDE TO THYMIC SELECTION OF T CELLS Article 18 July 2023 ANTIGEN PRESENTATION FOR CENTRAL TOLERANCE INDUCTION Article 18 September 2024 REPERTOIRE ANALYSES REVEAL T

CELL ANTIGEN RECEPTOR SEQUENCE FEATURES THAT INFLUENCE T CELL FATE Article 17 February 2022 REFERENCES * 1. Bevan, M. J. Nature 269, 417–418 (1977). 2. Zinkernagel, R. M. et al. J. exp.

Med. 147, 882–896 (1978). 3. Kisielow, P. et al. Nature 335, 730–733 (1988). 4. Sha, W. C. et al. Nature 336, 73–76 (1988). 5. Bjorkman, P. J. et al. Nature 329, 506–512 (1987). 6. Davis, M.

M. & Bjorkman, P. J. Nature 334, 395–402 (1988). 7. Claverie, J.-M., Prochnicka-Chalufour, A. & Bougueleret, L. Immun. Today 10, 10–14 (1989). 8. Chothia, C., Boswell, D. R. &

Lesk, A. M. EMBO J. 7, 3745–3755 (1988). 9. Nathenson, S. G. et al. A. Rev. Immun. 4, 471–502 (1986). 10. Bjorkman, P. J. et al. Nature 329, 512–518 (1987). 11. Bluestone, J. A. et al. J.

Immun. 137, 1244–1250 (1986). 12. Garrett, T. P. J. et al. Nature 342, 692–696 (1989). 13. Moore, M. W., Carbone, F. R. & Bevan, M. J. Cell 54, 777–785 (1988). 14. Ron, Y., Lo, D. &

Sprent, J. J. Immun. 137, 1764–1771 (1986). 15. Marrack, P. & Kappler, J. Immun. Today. 9, 308–315 (1988). 16. Marrack, P., McCormack, J. & Kappler, J. Nature 338, 503–505 (1989).

17. Kourilsky, P. & Claverie, J.–M. Celi 56, 327–329 (1989). 18. Ogata, M. ef al. J. Immun. 136, 1178–1185 (1986). 19. Singer, A. et al. Prog. Immun. VI, 60–66 (1986). 20. Fry, A. M.,

Cotterman, M. M. & Matis, L. A. J. Immun. 143, 2723–2729 (1989). 21. Kast, W. M., deWaal, L. P. & Meleif, C. J. M. J. exp. Med. 160, 1752–1766 (1984). 22. Carbone, F. R. & Bevan,

M. J. J. exp. Med. (in the press). 23. Bernstein, l. D., Tarn, M. R. & Nowinski, R. G. Science 207, 68–71 (1980). 24. Marshak-Rothstein, A. et al. J. Immun. 122, 2491–2497 (1979).

Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Immunology, Research Institute of Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, California, 92037,

USA Janko Nikolić-Z˘ugić & Michael J. Bevan Authors * Janko Nikolić-Z˘ugić View author publications You can also search for this author inPubMed Google Scholar * Michael J. Bevan View

author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Nikolić-Z˘ugić, J.,

Bevan, M. Role of self-peptides in positively selecting the T-cell repertoire. _Nature_ 344, 65–67 (1990). https://doi.org/10.1038/344065a0 Download citation * Received: 21 November 1989 *

Accepted: 05 January 1990 * Issue Date: 01 March 1990 * DOI: https://doi.org/10.1038/344065a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content:

Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative