Role of self-peptides in positively selecting the t-cell repertoire
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ABSTRACT THE fate of an immature thymocyte is determined by the specificity of its αβ T-cell receptor. Only cells expressing receptors that interact with sufficient affinity with major
histocompatibility complex (MHC) molecules expressed on thymus epithelial cells are positively selected and go on to mature and seed the peripheral lymphoid organs1–4. The H–2Kb class-I MHC
molecule positively selects for the maturation of cytotoxic ¤ lymphocytes that will respond in the periphery to H–2Kb cells presenting a foreign peptide. We have now analysed the ability of
variant H–2Kb molecules to positively select T-cells that respond to H–2Kb with ovalbumin. Our results indicate that self-peptides, presented in the groove of the class-I molecule on thymus
epithelial cells, are critically involved in positive selection of the T-cell repertoire. Furthermore, the ability of four different H–2Kb variants to select this response in the thymus
correlates with their ability to present the ovalbumin peptide, indicating that a self-peptide mimic of the foreign peptide could be involved in positive selection. Access through your
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Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Immunology, Research Institute of Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, California, 92037,
USA Janko Nikolić-Z˘ugić & Michael J. Bevan Authors * Janko Nikolić-Z˘ugić View author publications You can also search for this author inPubMed Google Scholar * Michael J. Bevan View
author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Nikolić-Z˘ugić, J.,
Bevan, M. Role of self-peptides in positively selecting the T-cell repertoire. _Nature_ 344, 65–67 (1990). https://doi.org/10.1038/344065a0 Download citation * Received: 21 November 1989 *
Accepted: 05 January 1990 * Issue Date: 01 March 1990 * DOI: https://doi.org/10.1038/344065a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content:
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