Cdna sequence of human apolipoprotein(a) is homologous to plasminogen

ABSTRACT Lipoprotein(a) is an LDL-like lipoprotein whose concentration in plasma is correlated with atherosclerosis. The characteristic protein component of lipoprotein(a) is

apolipoprotein(a) which is disulphide-linked to apolipoprotein B-100. Sequencing of cloned human apolipoprotein(a) complementary DMA shows that it is very similar to human plasminogen. It

contains a serine protease domain and two types of plasminogen-like kringle domains, one of which is present in 37 copies. Access through your institution Buy or subscribe This is a preview

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B100 BOUND TO THE LOW-DENSITY LIPOPROTEIN RECEPTOR Article 11 December 2024 APOLIPOPROTEIN-A1 TRANSPORTS AND REGULATES MMP2 IN THE BLOOD Article Open access 22 April 2025 THE STRUCTURE OF

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INFORMATION AUTHORS AND AFFILIATIONS * Department of Cardiovascular Research, Genentech, Inc., 460 Point San Bruno Boulevard, South San Francisco, California, 94080, USA John W. McLean, 

James E. Tomlinson, Dan L. Eaton & Richard M. Lawn * Department of Molecular Biology, Genentech, Inc., 460 Point San Bruno Boulevard, South San Francisco, California, 94080, USA Wun-Jing

Kuang & Ellson Y. Chen * Department of Medicine, Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, 60637, USA Gunther M. Fless & Angelo M. Scanu Authors

* John W. McLean View author publications You can also search for this author inPubMed Google Scholar * James E. Tomlinson View author publications You can also search for this author

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this author inPubMed Google Scholar * Ellson Y. Chen View author publications You can also search for this author inPubMed Google Scholar * Gunther M. Fless View author publications You can

also search for this author inPubMed Google Scholar * Angelo M. Scanu View author publications You can also search for this author inPubMed Google Scholar * Richard M. Lawn View author

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Kuang, WJ. _et al._ cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. _Nature_ 330, 132–137 (1987). https://doi.org/10.1038/330132a0 Download citation * Received: 08

September 1987 * Accepted: 12 October 1987 * Issue Date: 18 November 1987 * DOI: https://doi.org/10.1038/330132a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to

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