Low-density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta

ABSTRACT The vascular endothelium, in response to pulsatile flow and vaso-active agents including acetylcholine1,2, secretes the endothelium-derived relaxing factor (EDRF), a substance which

regulates vascular tone. Recent interest in EDRF has focused on its possible dysfunction in atherosclerosis1. In animal models of the disease, endothelium-dependent relaxation is markedly

reduced3,4. The continuous exposure of the endothelium in hyperlipidaemia to high concentrations of low-density lipoprotein (LDL), a known atherogenic risk factor, may explain this

dysfunction. Here, we demonstrate that pathophysiological concentrations of LDL directly inhibit endothelium-dependent relaxation. Chemically modified LDL, in contrast, is inactive, implying

that the inhibition is through a receptor-dependent mechanism. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS

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institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS CAVEOLIN-1 IS A PRIMARY DETERMINANT OF ENDOTHELIAL STIFFENING ASSOCIATED WITH

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2020 REFERENCES * 1. Vanhoutte, P. M., Rubanyi, G. M., Miller, V. M. & Houston, D. S. A. Rev. PhysioL 48, 307–320 (1986). 2. Furchgott, R. F. & Zawadzki, J. V. Nature 288, 373–376

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(1958). Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Biochemistry, Royal Free Hospital School of Medicine, London, NWS 2PF, UK H. E. Andrews, K. R.

Bruckdorfer & R. C. Dunn * Department of Pharmacology, Royal Free Hospital School of Medicine, London, NWS 2PF, UK M. Jacobs Authors * H. E. Andrews View author publications You can also

search for this author inPubMed Google Scholar * K. R. Bruckdorfer View author publications You can also search for this author inPubMed Google Scholar * R. C. Dunn View author publications

You can also search for this author inPubMed Google Scholar * M. Jacobs View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints

and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Andrews, H., Bruckdorfer, K., Dunn, R. _et al._ Low-density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta.

_Nature_ 327, 237–239 (1987). https://doi.org/10.1038/327237a0 Download citation * Received: 28 January 1987 * Accepted: 06 April 1987 * Issue Date: 21 May 1987 * DOI:

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