Antibodies to a cell-surface component coded by human chromosome 21 inhibit action of interferon

ANTICELLULAR sera able to block specific cell responses are important in the study of surface receptors. Particularly useful are antibodies against the human cellular antigens coded for by a

specific chromosome, which can be prepared by immunising mice with mouse–human somatic cell hybrids containing defined human chromosomes1. We have applied this method to the study of the

mechanism by which the presence of human chromosome 21 renders such hybrids sensitive to human interferon2. Interaction of an interferon with sensitive cells induces intracellular

biochemical changes, including the formation of an inhibitor of protein synthesis, making the cell unable to support virus replication3,4. We have obtained antibodies to hybrid cells

containing human chromosome 21, and these inhibit the response of live human cells to interferon. Our experiments indicate that chromosome 21 codes for a cell-surface component required as a

specific receptor for human interferon.

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