Crystal structure of proflavine, a dna binding agent

ABSTRACT THE subject of DNA–small molecule binding has received much attention in recent years. Particular emphasis has been placed on aminoacridine binding1, and many studies have employed

proflavine (Fig. 1) as perhaps the classical interacting agent of these series of drugs. The DNA-binding properties of proflavine cause it to act as a frameshift mutagen, and this ability

has been extensively utilised in molecular genetics2. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS

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institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS THE 8-17 DNAZYME CAN OPERATE IN A SINGLE ACTIVE STRUCTURE REGARDLESS OF METAL

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MOLECULE APPROACHES TO TARGETING RNA Article 26 January 2024 REFERENCES * Peacocke, A. R., in _The Acridinies_, (edit. by Acheson, R. M.), (John Wiley, New York, 1973). Google Scholar  *

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  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Biophysics, King's College, 26–29 Drury Lane, London, WC2B 5RL, UK S. NEIDLE & T.

A. JONES Authors * S. NEIDLE View author publications You can also search for this author inPubMed Google Scholar * T. A. JONES View author publications You can also search for this author

inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE NEIDLE, S., JONES, T. Crystal structure of proflavine, a DNA binding agent.

_Nature_ 253, 284–285 (1975). https://doi.org/10.1038/253284a0 Download citation * Received: 10 October 1974 * Issue Date: 24 January 1975 * DOI: https://doi.org/10.1038/253284a0 SHARE THIS

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