Effect of lithium on brain dopamine

ABSTRACT THE efficacy of lithium ion in the therapy of mania is now established1,2, and much speculation about its mode of action has involved its effects on brain catecholamine metabolism.

Treatment with lithium ion increases the turnover rate of whole brain noradrenaline2–4; increases intraneuronal while decreasing extraneuronal metabolism of noradrenaline3,4; increases

uptake of noradrenaline by synaptosomes5, and reduces the rate of release of 3H-noradrenaline caused by electrical stimulation of striatal slices6. The influence of lithium ion on brain

dopamine, however, is less fully documented. Here we describe the effect of chronic lithium chloride treatment on dopamine synthesis in striatal brain slices. Access through your institution

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OTHERS SUBCORTICAL VOLUME REDUCTION AND CORTICAL THINNING 3 MONTHS AFTER SWITCHING TO CLOZAPINE IN TREATMENT RESISTANT SCHIZOPHRENIA Article Open access 02 March 2022 TRANSLATIONAL EVIDENCE

FOR LITHIUM-INDUCED BRAIN PLASTICITY AND NEUROPROTECTION IN THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS Article Open access 05 July 2021 LITHIUM TREATMENT AND HUMAN HIPPOCAMPAL NEUROGENESIS

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Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Neuropsychopharmacology Research Unit, New York University Medical Center, 550 First Avenue, New York, New

York, 10016 EITAN FRIEDMAN & SAMUEL GERSHON Authors * EITAN FRIEDMAN View author publications You can also search for this author inPubMed Google Scholar * SAMUEL GERSHON View author

publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE FRIEDMAN, E., GERSHON, S. Effect

of Lithium on Brain Dopamine. _Nature_ 243, 520–521 (1973). https://doi.org/10.1038/243520a0 Download citation * Received: 16 January 1973 * Revised: 09 March 1973 * Issue Date: 29 June

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