Induction of differentiation of human myeloid leukemia cells by jasmonates, plant hormones

ABSTRACT Some regulators of plant growth and differentiation have been shown to induce the differentiation of several human myeloid leukemia cells, and might be effective as differentiation

inducers to control acute myelogenous leukemia cells. In this study, the growth-inhibiting and differentiation-inducing effects of jasmonates on human myeloid leukemia cells were examined.

Several myeloid leukemia cells were cultured with methyl jasmonate (MJ) and its derivatives. Cell differentiation was determined by nitroblue tetrazolium-reducing activity, morphological

changes, _α_-naphthyl acetate esterase activity and expression of differentiation-associated surface antigens. MJ induced both monocytic and granulocytic differentiation of HL-60 cells. MJ

activated mitogen-activated protein kinase (MAPK) in the cells before causing myelomonocytic differentiation. MAPK activation was necessary for MJ-induced differentiation, since PD98059, an

inhibitor of MAPK kinase, suppressed the differentiation induced by MJ. MJ also induced the differentiation of other human leukemia cell lines. Introduction of a double bond at the

4,5-position greatly enhanced the differentiation-inducing activity of MJ. MJ and its derivatives potently induce the differentiation of some myelomonocytic leukemia cells. One novel

derivative is a particularly promising therapeutic agent for the treatment of leukemia. Access through your institution Buy or subscribe This is a preview of subscription content, access via

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from the Ministry of Education, Culture, Sports, Science and Technology, Japan. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Saitama Cancer Center Research Institute, Saitama, Japan Y Ishii

 & Y Honma * Institute of Biological Science, Tsukuba University, Ibaraki, Japan Y Ishii & S Sakai * Graduate School of Agricultural Science, Tohoku University, Sendai, Japan H

Kiyota Authors * Y Ishii View author publications You can also search for this author inPubMed Google Scholar * H Kiyota View author publications You can also search for this author inPubMed

 Google Scholar * S Sakai View author publications You can also search for this author inPubMed Google Scholar * Y Honma View author publications You can also search for this author inPubMed

 Google Scholar CORRESPONDING AUTHOR Correspondence to Y Honma. ADDITIONAL INFORMATION Supplementary information accompanies this paper on the Cell Death and Differentiation website:

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Ishii, Y., Kiyota, H., Sakai, S. _et al._ Induction of differentiation of human myeloid leukemia cells by jasmonates, plant hormones. _Leukemia_ 18, 1413–1419 (2004).

https://doi.org/10.1038/sj.leu.2403421 Download citation * Received: 17 September 2003 * Accepted: 19 May 2004 * Published: 01 July 2004 * Issue Date: 01 August 2004 * DOI:

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currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * myeloid leukemia * differentiation * jasmonate * plant

hormone * differentiation therapy