Ac133 expression in human stem cells

ABSTRACT Expression of cell surface markers on human hematopoietic cells has provided a method for characterizing subsets of cells with distinct biological functions. This is largely due to

the ability to separate highly purified subpopulations of cells for comparative analysis. Relationships between the cell surface phenotype of these subpopulations and their proliferative and

differentiative capacity have been instrumental in defining the hierarchical organization of cells comprising the human hematopoietic system. The identification and isolation of human

hematopoietic cells expressing AC133, combined with use of _in vitro_ and _in vivo_ assays, has provided novel insights into the hematopoietic progenitor and stem cell compartment in the

human. More recent studies have offered evidence that AC133 expression is not limited to primitive blood cells, but also defines unique cell populations in non-hematopoietic tissues. These

findings will be reviewed here in the context of human hematopoiesis and the potential role and utility of AC133 expression in the human. Access through your institution Buy or subscribe

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PubMed  Google Scholar  Download references ACKNOWLEDGEMENTS This work was supported by a grant from the Cancer Research Society of Canada, and a scholarship award (No. MSH-35681) to MB from

the Canadian Institutes of Health Research, Ontario, Canada. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * The John P Robarts Research Institute, Developmental Stem Cell Biology, The

University of Western Ontario, Ontario, Canada M Bhatia Authors * M Bhatia View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS

Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Bhatia, M. AC133 expression in human stem cells. _Leukemia_ 15, 1685–1688 (2001). https://doi.org/10.1038/sj.leu.2402255

Download citation * Received: 23 April 2001 * Accepted: 19 June 2001 * Published: 06 November 2001 * Issue Date: 01 November 2001 * DOI: https://doi.org/10.1038/sj.leu.2402255 SHARE THIS

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Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * hematopoietic * stem cells * heterogeneity * endothelial progenitor * leukemia