Identification of 5α-androstane-3α, 17β-diol as a principal metabolite of pregnenolone in rat ovary at onset of puberty

ABSTRACT THE mechanism which initiates puberty in the female mammal is not yet understood. Donovan and van der Werff ten Bosch1 have suggested that gonadal steroids inhibit gonadotrophin

secretion in both young and adult animals and that this inhibition is mediated by the brain. Because the amount of steroid required to inhibit gonadotrophin secretion was lower in young than

in adult animals, it was assumed that the neural receptors of immature individuals are more sensitive to the negative feedback action of gonadal steroids. A fundamental step towards sexual

maturity would therefore be a reduction in the sensitivity of the hypothalamus to gonadal hormones. This hypothesis implies that the gonads are capable of adult activity before puberty, an

assumption which has yet to be proved. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through

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Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS LOCAL EFFECT OF ALLOPREGNANOLONE IN RAT OVARIAN STEROIDOGENESIS, FOLLICULAR AND CORPORA LUTEA DEVELOPMENT

Article Open access 16 March 2024 REDUCED GONADOTROPH STIMULATION BY ETHANOLAMINE PLASMALOGENS IN OLD BOVINE BRAINS Article Open access 26 February 2021 A POTENTIAL ROLE FOR THE ADRENAL

GLAND IN AUTISM Article Open access 07 September 2021 REFERENCES * Donovan, B. T., and van der Werff ten Bosch, J. J., _J. Physiol._, 147, 78 (1959). Article  CAS  Google Scholar  * Rubin,

B. L., Deane, H. W., Hamilton, J. A., and Driks, E. C., _Endocrinology_, 72, 924 (1963). Article  CAS  Google Scholar  * Weisz, J., and Lloyd, Ch. W., _Endocrinology_, 77, 735 (1965).

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AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Zoology, Hebrew University of Jerusalem, BENJAMIN ECKSTEIN * Laboratory of Natural Products, Hebrew University School of Pharmacy,

Jerusalem RAPHAEL MECHOULAM * Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts, 01545 SUMNER H. BURSTEIN Authors * BENJAMIN ECKSTEIN View author publications You can

also search for this author inPubMed Google Scholar * RAPHAEL MECHOULAM View author publications You can also search for this author inPubMed Google Scholar * SUMNER H. BURSTEIN View author

publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE ECKSTEIN, B., MECHOULAM, R.

& BURSTEIN, S. Identification of 5α-Androstane-3Α, 17Β-diol as a Principal Metabolite of Pregnenolone in Rat Ovary at Onset of Puberty. _Nature_ 228, 866–868 (1970).

https://doi.org/10.1038/228866a0 Download citation * Received: 20 February 1970 * Revised: 20 May 1970 * Issue Date: 28 November 1970 * DOI: https://doi.org/10.1038/228866a0 SHARE THIS

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