Ability of Haematopoietic Spleen Colonies to form Macrophages in vitro

THERE is substantial evidence that blood monocytes are the immediate precursors of macrophages in inflammatory exudates1,2 and in the peritoneal fluid3, and that bone marrow is a potential

source of these macrophages3–5. In previous work using the chromosome marker technique, and in vitro cultivation of macrophages, it was shown that in mouse radiation chimaeras, bone marrow

is a source of alveolar macrophages and of macrophages which can be cultured from different organs6. This work also suggested that only haematopoietic tissues contain precursor cells for

macrophages.

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