Effect of Acetylation on the Biological Activity of Pregnant Mare Serum Gonadotrophin
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DURING our recent investigation into the mechanism of action of pregnant mare serum gonadotrophin (PMS)1, we prepared a sample of highly radioactive peptide hormone. Radioactive steroid
hormones are relatively easy to prepare and have been utilized in investigations on the mechanism of action of these hormones2. More recently, radioactive peptide hormones have been
reported3–5 to have similar biological and antigenic properties to the native proteins. Acetylation of bovine growth hormone, utilizing tritiated acetic anhydride, resulted in a sample of
hormone biologically and antigenically equivalent to the native hormone3, while treatment of ACTH under similar conditions led to a loss of hormonal activity3. The results of our attempts to
acetylate PMS are now reported.
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