Formation of amines in the gastric mucosa of the rat

ABSTRACT HISTAMINE may have some role, as yet unknown, in the chemical regulation of gastric secretion1. This view is based on the effectiveness of histamine in producing acid secretion, on

the presence of histamine in the gastric juice, and on the high concentration of histamine in the gastric mucosa of several species. The rich supply of histamine in this tissue in the rat is

coincident with a high histidine decarboxylase activity2, probably indicating a local synthesis of the amine. Several animal tissues contain L-3,4-dihydroxyphenylalanine (DOPA)

decarboxylase, which attacks all aromatic amino-acids, including 5-hydroxytryptophan (5-HTP) and histidine3–5. This enzyme, however, decarboxylates histidine only inefficiently and the

physiological significance of this aspect of its function remains uncertain3,6. Another more specific histidine decarboxylase has been demonstrated in the foetal rat7,8 and in the bone

marrow of the adult rat9. In a recent investigation DOPA decarboxylase, as well as the specific histidine decarboxylase (cf. Weissbach _et al._3), were demonstrated in the gastric mucosa of

the rat10. While the presence of specific histidine decarboxylase seems to account for the formation of gastric histamine and ultimately for the postulated control of gastric secretion, the

physiological significance of a high gastric DOPA decarboxylase activity is unknown. Access through your institution Buy or subscribe This is a preview of subscription content, access via

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* Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS VEGETAL DIAMINE OXIDASE ALLEVIATES HISTAMINE-INDUCED CONTRACTION

OF COLONIC MUSCLES Article Open access 09 December 2020 SLEEVE GASTRECTOMY REVEALS THE PLASTICITY OF THE HUMAN GASTRIC EPITHELIUM Article Open access 20 January 2025 KINETIC STUDY ON THE

REACTION OF SODIUM NITRITE WITH NEUROTRANSMITTERS SECRETED IN THE STOMACH Article Open access 21 September 2023 REFERENCES * Code, C. F., in _CIBA Foundation Symposium on Histamine_, edit.

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_Proc. Soc. Exp. Biol. and Med._, 95, 392 (1957). Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pharmacology, University of

Lund, Sweden ROLF HÅKANSON Authors * ROLF HÅKANSON View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT

THIS ARTICLE CITE THIS ARTICLE HÅKANSON, R. Formation of Amines in the Gastric Mucosa of the Rat. _Nature_ 208, 793–794 (1965). https://doi.org/10.1038/208793a0 Download citation * Issue

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