Prevention of cholestanol-induced cholelithiasis by neomycin

ABSTRACT RABBITS receiving 0.25–1 per cent dietary cholestanol (5α-cholestan-3β-ol) for 3–6 weeks develop gall-stones which have been shown to consist predominantly of calcium, and sodium

glycoallodeoxycholate (3α-, 12α-dihydroxy-5α-cholanoyl glycine)1,2. Gall-stone formation in cholestanol-fed rabbits has been postulated to occur as follows: Cholestanol is absorbed from the

intestinal tract of the rabbit and is transported to the liver where some of the stanol is metabolized to allocholic acid (3α-, 7α-, 12α-trihydroxy-5α-cholanoic acid). The latter is

conjugated with glycine, excreted into the bile and eventually reaches the intestinal tract where it is hydrolysed and dehydroxylated by the intestinal bacterial flora to form

allodeoxycholic acid (3α-, 12α-dihydroxy-5α-cholanoic acid). This dihydroxy bile acid is reabsorbed and returns to the liver where it is conjugated with glycine and re-excreted into the bile

as glycoallodeoxycholate. The mixed calcium and sodium salt of the latter is relatively insoluble in bile2, and therefore is thought to be the cause of gall-stones in cholestanol-fed

rabbits. In contrast, the calcium–sodium salt of glycodeoxycholate is relatively soluble in aqueous media. Access through your institution Buy or subscribe This is a preview of subscription

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CHOLESTEROL GALLSTONE ASSOCIATED WITH OBESITY AND NORMAL WEIGHT Article Open access 23 April 2021 BILE ACID PROFILES IN ADULT PATIENTS WITH BILIARY ATRESIA WHO ACHIEVE NATIVE LIVER SURVIVAL

AFTER PORTOENTEROSTOMY Article Open access 30 January 2024 GUT MICROBIOTA PROMOTES CHOLESTEROL GALLSTONE FORMATION BY MODULATING BILE ACID COMPOSITION AND BILIARY CHOLESTEROL SECRETION

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AND AFFILIATIONS * Public Health Research Institute, New York E. H. MOSBACH, V. BOKKENHEUSER & D. P. CHATTOPADHYAY * Columbia University Research Service, Goldwater Memorial Hospital,

New York M. SCHMIDT & R. L. HIRSCH * Rockefeller Institute, New York A. F. HOFMANN Authors * E. H. MOSBACH View author publications You can also search for this author inPubMed Google

Scholar * V. BOKKENHEUSER View author publications You can also search for this author inPubMed Google Scholar * D. P. CHATTOPADHYAY View author publications You can also search for this

author inPubMed Google Scholar * M. SCHMIDT View author publications You can also search for this author inPubMed Google Scholar * R. L. HIRSCH View author publications You can also search

for this author inPubMed Google Scholar * A. F. HOFMANN View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions

ABOUT THIS ARTICLE CITE THIS ARTICLE MOSBACH, E., BOKKENHEUSER, V., CHATTOPADHYAY, D. _et al._ Prevention of Cholestanol-induced Cholelithiasis by Neomycin. _Nature_ 208, 1226–1227 (1965).

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