Role of liver in metabolism of chlorpromazine

ABSTRACT IN previous studies1 we demonstrated that the intact rat was capable of demethylating chlorpromazine-(N-methyl)-14C when production of carbon dioxide was used as an index of

demethylation. The liver seemed to be the likely tissue responsible for these findings, since Mueller and Miller2 had found that homogenates of rat liver were capable of demethylation. La Du

_et al._ 3 later developed a simpler system for demethylation using homogenates of rabbit, rat and guinea pig livers. However, using the system of La Du _et al._, Salzman and Brodie4

reported that no demethylation of chlorpromazine occurred with rabbit liver. Since we had observed the _in vivo_ demethylation of chlorpromazine, we decided to study its _in vitro_

demethylation by fortified homogenates of rabbit and rat liver prepared according to these procedures2,3. Access through your institution Buy or subscribe This is a preview of subscription

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(INMT) IS NOT ESSENTIAL FOR ENDOGENOUS TRYPTAMINE-DEPENDENT METHYLATION ACTIVITY IN RATS Article Open access 06 January 2023 _APC__MIN/+_ TUMOURS AND NORMAL MOUSE SMALL INTESTINES SHOW

LINEAR METABOLITE CONCENTRATION AND DNA CYTOSINE HYDROXYMETHYLATION GRADIENTS FROM PYLORUS TO COLON Article Open access 12 August 2020 ESTIMATING THE TIME OF LAST DRINKING FROM BLOOD ETHYL

GLUCURONIDE AND ETHYL SULPHATE CONCENTRATIONS Article Open access 22 August 2022 REFERENCES * Ross, jun., J. J., Young, R. L., and Maass, A. R., _Science_, 128, 1279 (1958). Article  ADS 

CAS  PubMed  Google Scholar  * Mueller, G. C., and Miller, J. A., _J. Biol. Chem._, 202, 579 (1953). CAS  PubMed  Google Scholar  * La Du, B. N., Gaudette, L., Trousef, N., and Brodie, B.

B., _J. Biol. Chem._, 214, 741 (1955). CAS  PubMed  Google Scholar  * Salzman, N. P., and Brodie, B. B., _J. Pharmacol. Exp. Therap._, 118, 46 (1956). CAS  Google Scholar  * Kamm, J. J.,

Gillette, J. R., and Brodie, B. B., _Fed. Proc._, 17, 382 (1958). Google Scholar  * Cook, L., (unpublished work). Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Smith

Kline and French Laboratories, Philadelphia R. L. YOUNG, J. J. Ross JUN. & A. R. MAASS Authors * R. L. YOUNG View author publications You can also search for this author inPubMed Google

Scholar * J. J. Ross JUN. View author publications You can also search for this author inPubMed Google Scholar * A. R. MAASS View author publications You can also search for this author

inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE YOUNG, R., Ross, J. & MAASS, A. Role of Liver in Metabolism of

Chlorpromazine. _Nature_ 183, 1396–1397 (1959). https://doi.org/10.1038/1831396a0 Download citation * Issue Date: 16 May 1959 * DOI: https://doi.org/10.1038/1831396a0 SHARE THIS ARTICLE

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