Pilot study of a multimodal intervention: mixed-type exercise and psychoeducation in patients undergoing allogeneic stem cell transplantation

ABSTRACT Substantial physical and functional deconditioning and diminished psychological wellbeing are all potential adverse effects of allogeneic stem cell transplantation (allo-HSCT). The

aim of this study was to evaluate the feasibility, safety and benefits (physical and functional capacity) of a 4–6 week supervised and structured mixed-type exercise, progressive relaxation

and psychoeducation programme in patients undergoing allo-HSCT. Nineteen patients were randomized to an intervention or a conventional care group (CC) and were tested for physical and

functional capacity before admission and upon hospital discharge. In all, 14 patients completed all study requirements (74%) and no adverse reactions that could be attributed to the

intervention were observed. At the time of discharge, the intervention group showed significant improvements in several muscle strength scores as compared to the CC group; chest press

(_P_=0.023), leg extension (_P_=0.007) and isometric right knee flexor (_P_=0.033). The intervention proved feasible, safe and well tolerated in this small sample of patients undergoing

allo-HSCT. An intervention of this type may be a useful strategy for maintaining or improving muscle strength, and minimizing loss of physical and functional capacity in patients undergoing

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customer support SIMILAR CONTENT BEING VIEWED BY OTHERS PREHABILITATIVE HIGH-INTENSITY INTERVAL TRAINING AND RESISTANCE EXERCISE IN PATIENTS PRIOR ALLOGENEIC STEM CELL TRANSPLANTATION

Article Open access 12 December 2023 FEASIBILITY OF EARLY-COMMENCING GROUP-BASED EXERCISE IN ALLOGENEIC BONE MARROW TRANSPLANTATION: THE BOOST STUDY Article 16 July 2021 HIGHER EXERCISE

TOLERANCE EARLY AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IS THE PREDICTIVE MARKER FOR HIGHER PROBABILITY OF LATER SOCIAL REINTEGRATION Article Open access 30 March 2021

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study participants, the staff and administration at the Department of Haematology, University Hospital of Copenhagen. This research was supported by grants from The Lundbeck Foundation, The

Novo Nordic Foundation, The Danish Cancer Society, The Copenhagen Hospital Corporation and The Danish Nursing Society. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of

Haematology, The University Hospital of Copenhagen, Copenhagen, Denmark M Jarden & D Hovgaard * The University Hospital's Centre for Nursing and Care Research, The University

Hospital of Copenhagen, Copenhagen, Denmark M Jarden, M Quist & L Adamsen * Department of Psychosocial Cancer Research, Danish Cancer Society, Copenhagen, Denmark E Boesen * University

of Copenhagen Faculty of Health Sciences, Copenhagen, Denmark L Adamsen Authors * M Jarden View author publications You can also search for this author inPubMed Google Scholar * D Hovgaard

View author publications You can also search for this author inPubMed Google Scholar * E Boesen View author publications You can also search for this author inPubMed Google Scholar * M Quist

View author publications You can also search for this author inPubMed Google Scholar * L Adamsen View author publications You can also search for this author inPubMed Google Scholar

CORRESPONDING AUTHOR Correspondence to M Jarden. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Jarden, M., Hovgaard, D., Boesen, E. _et al._ Pilot

study of a multimodal intervention: mixed-type exercise and psychoeducation in patients undergoing allogeneic stem cell transplantation. _Bone Marrow Transplant_ 40, 793–800 (2007).

https://doi.org/10.1038/sj.bmt.1705807 Download citation * Received: 15 January 2007 * Revised: 24 June 2007 * Accepted: 04 July 2007 * Published: 20 August 2007 * Issue Date: October 2007 *

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currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * allogeneic stem cell transplantation * cancer *

exercise * physical and functional capacity * multimodal intervention