Topical corticosteroid therapy for cicatricial conjunctivitis associated with chronic graft-versus-host disease

SUMMARY: A retrospective chart review was performed on seven patients treated with topical ocular corticosteroid therapy for progressive cicatricial conjunctivitis associated with chronic

graft-versus-host disease (GVHD) following hematopoietic stem cell transplantation. A clinical grading criteria for conjunctival GVHD based on the degree of cicatrization was developed and

patients graded prior to therapy. During the treatment course, the dose and frequency of topical corticosteroids and clinical outcomes were recorded. A complete response was defined as a

complete resolution of the conjunctival hyperemia with either total resolution of the conjunctival fibrovascularization or presence of inactive conjunctival scarring. Prednisolone acetate 1%

eye drops were used in a total of eight courses of therapy in seven patients. A complete response was documented in all seven patients with a total treatment duration of 7 weeks (median,

range: 3–16 weeks). Additional studies are required to determine the long-term safety and efficacy of topical corticosteroids for cicatricial conjunctivitis associated with ocular GVHD in

the context of a randomized, prospective clinical trial. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS

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institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS CORTICOSTEROID-SPARING TOPICAL TREATMENT WITH CYCLOSPORIN FOR JUVENILE

KERATOCONJUNCTIVITIS Article Open access 08 February 2025 THE OCULAR GRAFT-VERSUS-HOST DISEASE: THE PATH FROM CURRENT KNOWLEDGE TO FUTURE MANAGEMENTS Article 04 November 2022 A PLETHORA OF

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National Eye Institute, NIH, Bethesda, MD, USA M R Robinson, S S Lee, B I Rubin & K G Csaky * Pediatric Oncology Branch, National Cancer Institute, NIH, Bethesda, MD, USA A S Wayne *

Graft-versus-Host Disease and Autoimmunity Unit, Experimental Transplantation and Immunology Branch, National Cancer Institute, NIH, Bethesda, MD, USA S Z Pavletic * Experimental

Transplantation and Immunology Branch, National Cancer Institute, NIH, Bethesda, MD, USA M R Bishop * Stem Cell Allotransplantation Section, National Heart, Lung and Blood Institute, NIH,

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CORRESPONDING AUTHOR Correspondence to M R Robinson. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Robinson, M., Lee, S., Rubin, B. _et al._ Topical

corticosteroid therapy for cicatricial conjunctivitis associated with chronic graft-versus-host disease. _Bone Marrow Transplant_ 33, 1031–1035 (2004). https://doi.org/10.1038/sj.bmt.1704453

Download citation * Received: 30 September 2003 * Accepted: 09 December 2003 * Published: 29 March 2004 * Issue Date: 01 May 2004 * DOI: https://doi.org/10.1038/sj.bmt.1704453 SHARE THIS

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Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * conjunctiva * corticosteroid therapy * stem cell transplantation * graft-versus-host disease