Different immune reconstitution in multiple myeloma, chronic myeloid leukemia and acute myeloid leukemia patients after allogeneic transplantation of peripheral blood stem cells

ABSTRACT In this study we compared the lymphocyte reconstitution in 13 multiple myeloma (MM), nine acute myeloid leukemia (AML) and 10 chronic myeloid leukemia (CML) patients after

allogeneic G-CSF-mobilized PBSC transplantation from HLA-identical siblings. Conditioning regimens included standard total body irradiation + cyclophosphamide (CY), or busulphan + CY,

whereas VP-16 was added in patients with advanced disease. Overall comparable numbers of mononuclear cells, CD34+ cells and CD3+ T cells were infused in each group. A significantly higher

CD3+ T cell number was observed in MM and AML than in CML patients 1 month after transplant. However, MM patients showed a faster and better recovery of CD4+ T cells than both AML and CML

patients at 3 months (_P_ = 0.01 and _P_ = 0.01, respectively) and 12 months (_P_ = 0.01 _vs_ AML, while _P_ = NS _vs_ cml) after transplant, and had a cd4:cd8 ratio >1 with a median CD4+

t cell value >400/μl 1 year after transplant. development of acute graft-versus-host disease (gvhd) did not affect cd4:cd8 ratios but patients who experienced acute gvhd >grade I had

lower CD4+ and CD8+ t cell numbers at all time points. however, after excluding patients with gvhd >grade I, MM patients still showed a significantly higher CD4+ T cell value than

patients with myeloproliferative diseases 1 year after transplant. These findings suggest that although allogeneic PBSC transplantation induces rapid immune reconstitution, different

kinetics may occur among patients with hematological malignancies. In particular, the rapid reconstitution of CD4+ T cells in MM patients may contribute to the low transplant-related

mortality achieved in this disease. _Bone Marrow Transplantation_ (2000) 26, 1325–1331. Access through your institution Buy or subscribe This is a preview of subscription content, access via

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IMMUNE RECONSTITUTION IN MATCHED UNRELATED MYELOABLATIVE PERIPHERAL BLOOD STEM CELL TRANSPLANTATION Article Open access 13 July 2022 ANALYSIS OF EARLY EFFICACY AND IMMUNE RECONSTITUTION

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691–693 Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS This work was partially supported by Fondazione Cassa di Risparmio di Bologna (Bologna, Italy) and MURST (Rome,

Italy). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Institute of Hematology and Medical Oncology ‘Seràgnoli’, University of Bologna, Italy D Rondelli, F Re, G Bandini, M Arpinati, B

Senese, M Stanzani, F Bonifazi, S Falcioni, G Chirumbolo & S Tura * Department of Hematology, University of Siena, Italy D Raspadori Authors * D Rondelli View author publications You can

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author publications You can also search for this author inPubMed Google Scholar * G Chirumbolo View author publications You can also search for this author inPubMed Google Scholar * S Tura

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F., Bandini, G. _et al._ Different immune reconstitution in multiple myeloma, chronic myeloid leukemia and acute myeloid leukemia patients after allogeneic transplantation of peripheral

blood stem cells. _Bone Marrow Transplant_ 26, 1325–1331 (2000). https://doi.org/10.1038/sj.bmt.1702709 Download citation * Received: 28 June 2000 * Accepted: 24 September 2000 * Published:

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allogeneic PBSC transplant * multiple myeloma * acute myeloid leukemia * chronic myeloid leukemia * lymphocyte reconstitution * GVHD