Treatment of leukemic relapse following unrelated umbilical cord blood transplantation with interleukin-2: potential for augmenting graft-versus-leukemia and graft-versus-host effects with cytokines

ABSTRACT In comparison to bone marrow, umbilical cord blood has decreased intrinsic immune responsiveness allowing transplantation across HLA barriers with lower rates of graft-versus-host

disease. However, laboratory models have also suggested that cord blood may be extremely sensitive to stimulation by cytokines. We report an adult recipient of an _ex vivo_ expanded,

HLA-mismatched, unrelated cord blood transplant who experienced a late extramedullary relapse while still in hematologic remission. Despite demonstrating immune tolerance on minimal

immunosuppressive agents, a brief course of intravenous interleukin-2 resulted in rapid, aggressive graft-versus-host and graft-versus-leukemia reactions. This case highlights the potential

of cytokine immunomodulation following cord blood transplantation, but also suggests caution in stimulating these cells. _Bone Marrow Transplantation_ (2000) 26, 353–355. Access through your

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964–971 CAS  PubMed  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Adult Blood and Marrow Transplant Program, Hackensack University Medical Center,

Hackensack, NJ, USA SL Goldberg, AL Pecora, RJ Rosenbluth & AA Jennis * Progenitor Cell Therapy, Hackensack, NJ, USA RA Preti Authors * SL Goldberg View author publications You can also

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al._ Treatment of leukemic relapse following unrelated umbilical cord blood transplantation with interleukin-2: potential for augmenting graft-versus-leukemia and graft-versus-host effects

with cytokines. _Bone Marrow Transplant_ 26, 353–355 (2000). https://doi.org/10.1038/sj.bmt.1702520 Download citation * Received: 04 February 2000 * Accepted: 16 May 2000 * Published: 28

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shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * umbilical

cord blood * interleukin-2 * graft-versus-leukemia * graft-versus-host disease * leukemic relapse