Successful treatment of advanced natural killer cell lymphoma with high-dose chemotherapy and syngeneic peripheral blood stem cell transplantation

ABSTRACT CD56+ angiocentric lymphoma has currently been recognized as a distinct clinical entity which is the prototype of the putative NK cell lymphomas. A 16-year-old Japanese girl with

advanced CD56+ angiocentric lymphoma received high-dose chemotherapy supported with syngeneic peripheral blood stem cell transplantation (PBSCT). Prior to syngeneic PBSCT, she received six

cycles of conventional chemotherapy before transplantation, resulting in a partial response. PBSC were mobilized with granulocyte colony-stimulating factor (G-CSF) and collected from her

identical twin. High-dose cyclophosphamide, MCNU, etoposide, and carboplatin were used for pretransplant conditioning. Syngeneic PBSCT was well tolerated. She achieved complete remission and

is now surviving in continuous complete remission for more than 30 months after syngeneic PBSCT. Thus, marrow-ablative chemotherapy facilitated by autologous or allogeneic PBSCT should be

considered as part of the primary therapy for poor prognosis NK cell lymphomas. Access through your institution Buy or subscribe This is a preview of subscription content, access via your

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T-CELL LYMPHOMA: THE IMPACT OF DIFFERENT DONOR TYPE ON OUTCOME Article 15 November 2020 RESULTS OF A MULTICENTER PHASE I/II TRIAL OF TCRΑΒ AND CD19-DEPLETED HAPLOIDENTICAL HEMATOPOIETIC STEM

CELL TRANSPLANTATION FOR ADULT AND PEDIATRIC PATIENTS Article Open access 24 December 2021 ALLOGENEIC STEM CELL TRANSPLANTATION FOR PATIENTS WITH AGGRESSIVE NK-CELL LEUKEMIA Article 10

August 2020 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Second Department of Internal Medicine, Okayama University Medical School, Shikata-Cho, Okayama, Japan Y Nawa, K Takenaka, K

Shinagawa, S Deguchi, N Matsumura, S Koyama, Y Hiramatsu, E Omoto & M Harada * Second Department of Pathology, Okayama University Medical School, Shikata-Cho, Okayama, Japan T Yoshino

Authors * Y Nawa View author publications You can also search for this author inPubMed Google Scholar * K Takenaka View author publications You can also search for this author inPubMed 

Google Scholar * K Shinagawa View author publications You can also search for this author inPubMed Google Scholar * S Deguchi View author publications You can also search for this author

inPubMed Google Scholar * N Matsumura View author publications You can also search for this author inPubMed Google Scholar * S Koyama View author publications You can also search for this

author inPubMed Google Scholar * Y Hiramatsu View author publications You can also search for this author inPubMed Google Scholar * E Omoto View author publications You can also search for

this author inPubMed Google Scholar * T Yoshino View author publications You can also search for this author inPubMed Google Scholar * M Harada View author publications You can also search

for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Nawa, Y., Takenaka, K., Shinagawa, K. _et al._ Successful

treatment of advanced natural killer cell lymphoma with high-dose chemotherapy and syngeneic peripheral blood stem cell transplantation. _Bone Marrow Transplant_ 23, 1321–1322 (1999).

https://doi.org/10.1038/sj.bmt.1701803 Download citation * Received: 20 August 1998 * Accepted: 25 January 1999 * Published: 15 June 1999 * Issue Date: 01 June 1999 * DOI:

https://doi.org/10.1038/sj.bmt.1701803 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not

currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * natural killer cell lymphoma * high-dose chemotherapy *

peripheral blood stem cell transplantation * granulocyte colony-stimulating factor