Formation of derivatives of thyroxine from derivatives of diiodotyrosine

ABSTRACT THE observation of von Mutzenbecher1 that traces of thyroxine are formed on incubation of an alkaline solution of diiodotyrosine was developed by Harington and Pitt Rivers2. These

authors showed that the course of the reaction was greatly influenced by _p_H ; the largest yield of thyroxine, amounting to 2.7 per cent calculated on the diiodotyrosine not recoverable at

the end of the oxidation, was obtained at _p_H 10; at this _p_H the acidic groups of diiodotyrosine are 95 per cent neutralized. In highly alkaline solution, there was little destruction of

diiodotyrosine and no thyroxine formation : at lower alkalinity (_p_H 8–9) the destruction of diiodotyrosine was very extensive and the formation of thyroxine was minute. In all experiments

in which diiodotyrosine was oxidatively destroyed, tarry by-products appeared and the liberation of ammonia was evident. Access through your institution Buy or subscribe This is a preview of

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REVEALED BY A CRYO-EM STRUCTURE OF NATIVE BOVINE THYROGLOBULIN Article Open access 02 May 2022 THYROXINE BINDING TO TYPE III IODOTHYRONINE DEIODINASE Article Open access 21 September 2020

AUTOANTIBODY MIMICRY OF HORMONE ACTION AT THE THYROTROPIN RECEPTOR Article 08 August 2022 REFERENCES * von Mutzenbecher, P., _Z. Physiol. Chem._, 261, 253 (1939). Article  Google Scholar  *

Harington, C. R., and Pitt Rivers, R. V., _Biochem. J._, 39, 157 (1945). Article  CAS  Google Scholar  * Ashley, J. N., and Harington, C. R., _Biochem. J._, 23, 1178 (1929). Article  CAS 

Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * National Institute for Medical Research, London, N.W.3. ROSALIND PITT RIVERS Authors * ROSALIND PITT RIVERS

View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE RIVERS, R. Formation

of Derivatives of Thyroxine from Derivatives of Diiodotyrosine. _Nature_ 161, 308 (1948). https://doi.org/10.1038/161308a0 Download citation * Issue Date: 28 February 1948 * DOI:

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