Adiposity, insulin and lipid metabolism in post-menopausal women

ABSTRACT OBJECTIVE: To investigate relationships between body fat and its distribution and carbohydrate and lipid tolerance using statistical comparisons in post-menopausal women. DESIGN:

Sequential meal, postprandial study (600 min) which included a mixed standard breakfast (30 g fat) and lunch (44 g fat) given at 0 and 270 min, respectively, after an overnight fast.

SUBJECTS: Twenty-eight post-menopausal women with a diverse range of body weight (body mass index (BMI), mean 27.2, range 20.5–38.8 kg/m2) and abdominal fat deposition (waist, mean 86.4,

range 63.5–124.0 cm). Women with BMI <18 or >37 kg/m2, age>80 y and taking hormone replacement therapy (HRT) were excluded. MEASUREMENTS: Anthropometric measurements were performed

to assess total and regional fat deposits. The concentrations of plasma total cholesterol, high density lipoprotein (HDL) cholesterol, triacylglycerol (TAG), glucose, insulin (ins),

non-esterified fatty acids (NEFA) and apolipoprotein (apo) B-48 were analysed in plasma collected at baseline (fasted state) and at 13 postprandial time points for a 600 min period. RESULTS:

Insulin concentrations in the fasted and fed state were significantly correlated with all measures of adiposity (BMI, waist, waist–hip ratio (W/H), waist–height ratio (W/Ht) and sum of

skinfold thickness (SSk)). After controlling for BMI, waist remained significantly and positively associated with fasted insulin (_r_=0.559) with waist contributing 53% to the variability

after multiple regression analysis. After controlling for waist, BMI remained significantly correlated with postprandial (IAUC) insulin (_r_=0.535) contributing 66% of the variability of

this measurement. No association was found between any measures of adiposity and glucose concentrations, although insulin concentration in relation to glucose concentration (glucose–insulin

ratio) was significantly negatively correlated with all measures of adiposity. A significant positive correlation was found between fasted TAG and BMI (_r_=0.416), waist (_r_=0.393) and Ssk

(_r_=0.457) and postprandial (AUC) TAG with BMI (_r_=0.385) and Ssk (_r_=0.406). A significantly higher postprandial apolipoprotein (apo) B-48 response was observed in those women with high

BMI (>27 kg/m2). Fasting levels of NEFA were significantly and positively correlated with all measures of adiposity (except W/H). No association was found between cholesterol containing

particles and any measure of adiposity. CONCLUSION: Hyperinsulinaemia associated with increasing body fat and central fat distribution is associated with normal glucose but not TAG or NEFA

concentrations in postmenopausal women. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through

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Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS DISTINCT OPPOSING ASSOCIATIONS OF UPPER AND LOWER BODY FAT DEPOTS WITH METABOLIC AND CARDIOVASCULAR DISEASE

RISK MARKERS Article 30 July 2021 ADIPOSE TISSUE INSULIN RESISTANCE INDEX WAS INVERSELY ASSOCIATED WITH GLUTEOFEMORAL FAT AND SKELETAL MUSCLE MASS IN JAPANESE WOMEN Article Open access 16

July 2024 FACTORS ASSOCIATED WITH BODY WEIGHT GAIN AND INSULIN-RESISTANCE: A LONGITUDINAL STUDY Article Open access 22 April 2024 REFERENCES * Colditz GA, Willet WC, Stampfer MJ, Rosner B,

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44–49. Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS The authors would like to thank members of the Hugh Sinclair Unit of Human Nutrition for their invaluable help on

the postprandial study day. Thanks must also go to Helen Osborne for her help with sample analysis and Dr Mohamed-Ali for insulin analysis. We are also indebted to the subjects without whom

the study would not have been possible. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading,

Berkshire, UK JA Lovegrove, KDRR Silva, JW Wright & CM Williams Authors * JA Lovegrove View author publications You can also search for this author inPubMed Google Scholar * KDRR Silva

View author publications You can also search for this author inPubMed Google Scholar * JW Wright View author publications You can also search for this author inPubMed Google Scholar * CM

Williams View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to JA Lovegrove. RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Lovegrove, J., Silva, K., Wright, J. _et al._ Adiposity, insulin and lipid metabolism in post-menopausal women. _Int J Obes_ 26, 475–486

(2002). https://doi.org/10.1038/sj.ijo.0801963 Download citation * Received: 23 January 2001 * Revised: 14 November 2001 * Accepted: 26 November 2001 * Published: 28 March 2002 * Issue Date:

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shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * post-menopausal * women *

triacylglycerol * postprandial * insulin resistance * coronary heart disease * central adiposity * body fat * apolipoprotein B-48